Imaging to Study Solid Tumor Origin and Progression: Lessons from Research and Clinical Oncology

The document reviewed the role of advanced imaging techniques in understanding the origin and progression of solid tumors, focusing on cancer stem cells (CSCs) and the tumor microenvironment. Techniques like fluorescence imaging, bioluminescence imaging (BLI), and intravital microscopy provided insights into tumor initiation, growth, and metastasis, particularly in cancers such as basal cell carcinoma, colon, breast, and lung cancer. Clinical imaging advancements, including PET, PET/CT, and MRI, were crucial for early detection and treatment monitoring. The development of molecular imaging and theranostic compounds aimed to enhance targeted therapy with minimal toxicity. Despite significant progress, challenges such as high doses of ionizing radiation and unanswered questions in cancer research indicated the need for ongoing research.