Search
for

    Did you mean Fibroblasts?
    Glossary Fibroblasts

    specialized cells that produce and maintain connective tissue

    Fibroblasts are specialized cells found in connective tissue that play a crucial role in wound healing and tissue repair. They produce and maintain the extracellular matrix, which provides structural support to tissues, and are essential for the synthesis of collagen, a key protein that helps maintain skin elasticity and strength.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Distinct fibroblast lineages determine dermal architecture in skin development and repair Nature · 2013 · 1235 citations
    2. Fibroblasts: Origins, definitions, and functions in health and disease Cell · 2021 · 488 citations
    3. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018 · 418 citations
    4. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds Nature Communications · 2019 · 301 citations
    5. Fibroblast heterogeneity: implications for human disease Journal of Clinical Investigation · 2018 · 299 citations
    6. Intradermal adipocytes mediate fibroblast recruitment during skin wound healing Development · 2013 · 238 citations
    7. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018 · 225 citations
    8. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    9. Macrophages and fibroblasts during inflammation and tissue repair in models of organ regeneration Regeneration · 2017 · 201 citations
    10. Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018 · 159 citations
    11. Fibroblast growth factors: key players in regeneration and tissue repair Development · 2017 · 154 citations
    12. Fibroblasts and wound healing: an update Regenerative Medicine · 2018 · 146 citations
    13. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations
    14. Fibroblast state switching orchestrates dermal maturation and wound healing Molecular Systems Biology · 2018 · 126 citations
    15. The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development The EMBO Journal · 2007 · 125 citations
    16. Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020 · 123 citations
    17. Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction Trends in Cell Biology · 2014 · 119 citations
    18. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages Nature Communications · 2016 · 115 citations
    19. Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial–Mesenchymal Interactions 1999 · 92 citations
    20. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007 · 75 citations
    21. Fibroblasts – the cellular choreographers of wound healing Frontiers in Immunology · 2023 · 74 citations
    22. Alteration of Skin Properties with Autologous Dermal Fibroblasts International Journal of Molecular Sciences · 2014 · 67 citations
    23. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells 2007 · 66 citations
    24. Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors Nature Communications · 2014 · 66 citations
    25. Fibroblast Growth Factors Stimulate Hair Growth through<i>β</i>-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015 · 64 citations
    26. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    27. Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds PLOS ONE · 2015 · 62 citations
    28. Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles Developmental Biology · 1993 · 58 citations
    29. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    30. Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects Journal of Materials Chemistry B · 2017 · 49 citations