Repigmentation in Skin of Color After Phenol-Croton Oil Chemical Peel

November 2023 in “ Journal of the American Academy of Dermatology ”

Marcelo Paiva, Aline S. Justo, Bruna Mikulis Lemes, Anna Claudia M. O. Capote, Mayra B.C. Maymone, Leandro Cavalcante Lipinski, Peter R. Rullan, Flávio Luís Beltrame, Hélio Amante Miot, Carlos Gustavo Wambier

phenol-croton oil chemical peel hypopigmentation repigmentation leukoderma eumelanin fibroblast epidermal regeneration wound healing skin repigmentation skin hypopigmentation skin leukoderma melanin skin fibroblast skin healing

TLDR Skin of color can spontaneously repigment after a phenol-croton oil chemical peel.

The study investigates the effects of phenol-croton oil chemical peels on skin of color (SOC), focusing on repigmentation post-treatment. Using a porcine model and clinical observations of patients with Fitzpatrick V and VI skin types, the study found that temporary hypopigmentation observed on day 7 resolved by day 21, with normal pigmentation restored. Histological analysis showed fewer melanosomes but satisfactory collagen regeneration. This suggests that despite initial hypopigmentation, SOC can spontaneously repigment after deep chemical peels, challenging previous concerns about the safety of such treatments in SOC.

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Repigmentation in Skin of Color After Phenol-Croton Oil Chemical Peel

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