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This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.

This review explores how combining extracellular vesicles with hydrogels and utilizing 3D bioprinting technologies creates innovative composite systems for wound healing, offering advanced mechanical and biological support, while addressing challenges like degradation and regulatory issues in clinical applications.

This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells.

This study introduced a viscoelastic dry electrode that successfully reduces motion artifacts in EP monitoring on hairy skin, maintaining stable performance for up to 48 days.

This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

This review discusses the therapeutic potential and challenges of using extracellular vesicles derived from mesenchymal stem cells, concluding that they may have a comparable therapeutic potential to the original cells despite current challenges in their application and production.

This case series observed that patients with persistent post-COVID-19 symptoms reported considerable improvement after using icosapent ethyl, suggesting potential therapeutic success warranting further research.

This review discusses the potential of biomimetic synthetic vesicles to advance precision diagnostics and medicine by combining the beneficial properties of naturally occurring extracellular vesicles and synthetic nanoparticles, although no new clinical results are reported.

This review examines various methods for purifying extracellular vesicles loaded with drugs, highlighting their principles, benefits, and drawbacks, and stresses the importance of standardized guidelines to enhance the reproducibility of EV-based drug delivery research.

This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.

In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.

This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This review discusses the role of extracellular vesicles in psoriasis pathogenesis and their potential as therapeutic agents or drug delivery systems, but it reports no new clinical findings.

This study suggests that extracellular vesicles derived from Saccharomyces cerevisiae may enhance hair follicle-related cellular processes, highlighting their potential for biomedical and cosmetic applications.

This study evaluated the safety and efficacy of Bio-Pulsed avian mesenchymal stem cell-derived small extracellular vesicles when applied topically, finding significant improvements in hair growth, skin rejuvenation, and regenerative microRNA presence among 60 human participants without adverse events.

This study demonstrated that gelatine-based hydrogel foams loaded with platelet extracellular vesicles (pEVs) promoted full wound closure in a chronic wound rat model within 14 days, suggesting potential for personalized treatment of chronic diabetic wounds.

In this study, human dermal papilla cell-derived extracellular vesicles (hDPC-EVs) were found to reduce skin fibrosis in mice by delivering miRNA-182-5p, which inhibits the TGF-β1 signaling pathway.

This study found that echogenic liposomes improved the delivery and penetration of CRISPR/Cas9 genetic materials into cardiomyocytes, both in vitro and in vivo, especially when combined with ultrasound, highlighting a promising strategy for cardiovascular gene therapy.

Microfluidic models improve testing for aging, wound healing, and oral tissue, reducing animal testing.

This review discusses current research and interest in extracellular vesicles for applications in plastic surgery and underscores the need for standardized protocols and further evidence to inform clinical use.

This review discusses the dual role of extracellular vesicles in the pathophysiology and treatment of atopic dermatitis but reports no new clinical results; future research should address standardization and safety challenges.

This article introduces the concept of organ size control in regeneration, regulated by the Hippo signaling pathway, but reports no new experimental results.

This study found that para-phenylenediamine induces cytotoxic effects in normal human hair dermal papilla cells by altering microRNA expression and causing cell death, cell cycle arrest, and oxidative stress.

This review discusses the role of extracellular vesicles in bone regeneration and their potential as therapeutics, highlighting challenges like standardization and safety for clinical application, but it reports no new clinical results.

E13 fetal mouse fibroblast vesicles may help reduce scarring.

In this study, extracellular vesicles from Saccharomyces cerevisiae demonstrated multifunctional bioactivity, enhancing cell proliferation and migration, reducing inflammation, and promoting collagen gene expression in hair follicle–related cells.

This study utilized a pigmented human epidermal equivalent model to incorporate melanocytes into the epidermis and found enhanced differentiation potential compared to conventional in vitro systems, reflecting in vivo cellular trajectories and highlighting melanocyte-to-keratinocyte communication pathways.