Induced Mammary Epithelial Cell-Derived Extracellular Vesicles Promote the Repair of Skin Trauma

    October 2025 in “ International Journal of Molecular Sciences ”
    Shufen Pan, Dandan Zhang, Guodong Wang, Longfei Sun, Mengzhen Wei, Shan Deng, Jianwei Chen, Prasanna Kallingappa, Xiang Yuan, Ben Huang
    Studysummary This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model. Our plain-language summary of this paper — not a Tressless recommendation.
    This study demonstrates that extracellular vesicles (EVs) derived from chemically induced mammary epithelial cells (CiMECs) significantly enhance skin wound repair when combined with a chitosan hydrogel, forming a composite system (CMECG). In a rat model, CMECG improved wound closure efficiency from 70% to 90% over 14 days, promoting fibroblast and mammary epithelial cell proliferation and migration, and enhancing collagen synthesis and remodeling. The therapeutic effects are attributed to miRNAs within CiMECs-EVs, which regulate cell proliferation, migration, angiogenesis, and inflammation through pathways like MAPK and PI3K-Akt. The study highlights CMECG as a promising strategy for clinical skin wound treatment, with optimal doses differing between in vitro (12.5 μg) and in vivo (200 μg) settings. Despite limitations such as a short follow-up period, the findings suggest potential for enhancing skin wound repair.
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