Multifunctional Bioactivity of Saccharomyces Cerevisiae Extracellular Vesicle in Hair Follicle-Related Cellular Models

This study investigates the bioactivity of extracellular vesicles (EVs) derived from Saccharomyces cerevisiae (beer yeast) in hair follicle-related cellular models. The EVs were isolated and characterized, showing typical EV size and a negatively charged surface. In human dermal papilla cells, keratinocytes, and dermal fibroblasts, the yeast-derived EVs enhanced cell proliferation, promoted cell migration, reduced pro-inflammatory cytokine expression, and increased collagen-related gene expression, all without cytotoxic effects. Additionally, the EVs demonstrated antioxidant activity. These results suggest that S. cerevisiae-derived EVs have multifunctional bioactivity that could be used to regulate hair follicle microenvironmental homeostasis, highlighting their potential as scalable bioactive platforms for hair-related applications.