31 citations
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February 2014 in “Journal of dermatological science” This study found that placental growth factor (PlGF) enhanced hair shaft elongation and accelerated hair follicle growth, suggesting its potential as a therapeutic target for alopecia.
28 citations
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February 2019 in “Genes” This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.
22 citations
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February 2017 in “Clinical and Experimental Dermatology” This study suggests that icariin promotes hair follicle growth in mice by enhancing IGF-1 expression in dermal papilla cells.
18 citations
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January 2017 in “PloS one” This study identified 295 genes with differential expression in Yangtze River Delta White Goats that produce high-quality brush hair, suggesting these genes and the MAPK signaling pathway may influence hair quality traits.
10 citations
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August 2018 in “Experimental Dermatology” This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.
9 citations
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November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
8 citations
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June 2019 in “Scientific Reports” This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.
8 citations
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January 2016 in “Evidence-based Complementary and Alternative Medicine” This study found that Rumex japonicus Houtt. root extract promoted hair growth by enhancing cell proliferation and preventing apoptosis in human dermal papilla cells and HaCaT cells, as well as in a mouse model.
6 citations
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August 2024 in “Experimental Dermatology” This study found that irisin, a myokine, increases hair growth by activating the Wnt/β-catenin pathway, enhancing cell proliferation and hair shaft elongation in both human cell and mouse models.
4 citations
,
June 2021 in “Journal of Microbiology and Biotechnology” This study found that ginsenoside Rg4 enhanced hair-inductive properties of dermal papilla cells via the AKT/GSK3β/β-catenin pathway, suggesting its potential as a natural therapy for hair growth.
3 citations
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April 2010 in “Endocrinology” This review discusses the mechanisms of androgenic alopecia and reports no new results; the development of a mouse model for further study is described.
2 citations
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November 2023 in “Biomolecules” This review article analyzes the role of the WNT signaling pathway in skin development, wound healing, and mechanical stretching, emphasizing its importance in understanding and potentially advancing treatments for skin-related diseases.
1 citations
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May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This meeting synopsis on the 66th Annual Montagna Symposium reports no new results but outlines discussions on precision dermatology, integrating molecular insights with clinical applications for personalized skin care.
1 citations
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April 2006 in “International Journal of Oncology” In this study, lysocellin induced G1 phase arrest in human osteosarcoma cells, but diminished the cytotoxic efficacy of etoposide, while its derivative alopestatin may reduce etoposide-induced alopecia in a rat model.
June 2026 in “Frontiers in Cell and Developmental Biology” This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.
March 2026 in “Frontiers in Veterinary Science” This study found that all-trans retinoic acid (ATRA) inhibits proliferation and promotes apoptosis in secondary hair follicle-derived dermal papilla cells from cashmere goats, likely via the TGF-β2/Smad2/3 signaling pathway.
October 2025 in “Frontiers in Veterinary Science” This study found that treating secondary hair follicle stem cells from Arbas cashmere goats with 10 μg/mL quercetin for 48 hours significantly boosted cell proliferation and reduced apoptosis by activating several signaling pathways, suggesting a potential strategy to enhance cashmere production.
October 2025 in “Phytomedicine” This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.
September 2025 in “Frontiers in Medicine” This study found that angiopoietin-1 significantly reduces apoptosis and promotes proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting its potential as a therapeutic candidate for androgenetic alopecia.
This study found that supercritical fluid extraction of germinated perilla seed significantly promoted hair follicle cell proliferation and gene expression related to hair growth, suggesting its potential as a natural treatment for hair loss.
April 2025 in “International Journal of Molecular Sciences” In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.
January 2024 in “Biological & clinical sciences research journal” This review of 355 articles found that apigenin, a compound found in many plants and vegetables, is mainly researched for its anti-inflammatory, neuroprotective, and anti-cancer properties, with enhanced efficacy when combined with allopathic drugs.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrated that disrupting EGFR signaling in mice leads to immune sensitivity compromising the hair follicle's protective environment, but JAK1/2 inhibition can restore this immune privilege and stimulate hair growth, suggesting a potential therapy for scarring hair loss diseases like cicatricial alopecia.
August 2023 in “Research Square (Research Square)” This study found that two microRNAs, oar-miR-23b and oar-miR-133, inhibit the development of hair follicles in superfine wool sheep by targeting genes involved in key signaling pathways, suggesting their potential use as molecular markers for breeding fine wool sheep.
This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.
This study found that low-level laser therapy may enhance wound healing and reduce pain, swelling, and inflammation by increasing mitochondrial activity and oxidative stress, leading to greater protein synthesis and cell proliferation.
This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
August 2025 in “Stem Cell Research & Therapy” This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.
April 2025 in “Regenerative Therapy” This study found that PRP-Exos may stimulate hair follicle growth and enhance regeneration in cases of AGA by activating the Wnt/β-Catenin signaling pathway, showing potential both in vitro and in vivo.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.