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    Glossary Epithelial Keratins

    Epithelial keratins are a group of fibrous proteins that form a key component of the cytoskeleton in epithelial cells, including those in the hair follicle. They play a crucial role in maintaining the structural integrity and resilience of hair and skin. In the context of hair loss, abnormalities or mutations in keratin genes can lead to conditions such as alopecia or other hair disorders, highlighting their importance in hair biology and health. Key distinguishing characteristics include their ability to form intermediate filaments, which provide mechanical support and protection to cells.

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    1. Hair Keratins and Hair Follicle–Specific Epithelial Keratins Methods in cell biology · 2004 · 31 citations
    2. Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and β‐catenin in a malignant pilomatricoma: a histological and immunohistochemical study Journal of Cutaneous Pathology · 2005 · 27 citations
    3. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification International Journal of Dermatology · 2013 · 12 citations
    4. Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma Frontiers in Medicine · 2022 · 3 citations
    5. Immunhistochemische und biochemische Untersuchungen zur Expression von epithelialen Keratinen in klinisch unveränderter Pferdehaut und Fußhaut von Kaltblutpferden mit Warzenmauke-Syndrom 2007
    6. Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions Plastic & Reconstructive Surgery · 2003 · 25 citations
    7. Assembly of Hair Keratins in Transfected Epithelial Cells Biochemical and Biophysical Research Communications · 1996 · 5 citations
    8. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    9. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    10. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    11. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    12. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation Differentiation · 1992 · 28 citations
    13. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    14. Keratin cytoskeletons in epithelial cells of internal organs Proceedings of the National Academy of Sciences · 1979 · 482 citations
    15. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    16. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    17. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    18. Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial–Mesenchymal Interactions 1999 · 92 citations
    19. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization Development · 1991 · 83 citations
    20. Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005 · 58 citations
    21. Suprabasal change and subsequent formation of disulfide-stabilized homo- and hetero-dimers of keratins during esophageal epithelial differentiation Journal of Cell Science · 1993 · 28 citations
    22. Keratins: Dynamic, flexible structural proteins of epithelial cells Current problems in dermatology · 2001 · 13 citations
    23. Revisiting the significance of keratin expression in complex epithelia Journal of cell science · 2022 · 6 citations
    24. Revisiting the significance of keratin expression in complex epithelia bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    25. Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression American Journal of Dermatopathology · 2025
    26. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Development · 2013 · 60 citations
    27. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    28. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Journal of Cell Science · 2013 · 3 citations
    29. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    30. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations