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    Glossary Epidermal Proliferation

    rapid cell division in skin's outermost layer

    Epidermal proliferation refers to the process by which cells in the outermost layer of the skin, known as the epidermis, rapidly divide and multiply. This process is crucial for skin regeneration and repair, helping to replace dead or damaged cells and maintain the skin's protective barrier. In conditions like psoriasis, this proliferation can become excessive, leading to thickened, scaly patches of skin.

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    1. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012 · 221 citations
    2. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    3. Urokinase is a Positive Regulator of Epidermal Proliferation In Vivo Journal of Investigative Dermatology · 1999 · 28 citations
    4. Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis Journal of Investigative Dermatology · 2011 · 15 citations
    5. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    6. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    8. The relevance of collagen XVII expression in epidermal differentiation and proliferation Journal of dermatological science · 2016
    9. Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23 Journal of cosmetic dermatology · 2023
    10. Increased proliferation of epidermal gamma delta T cells and expression of the transmembrane protein, BST2, in Alopecia areata 2022 · 2 citations
    11. High proliferation and delamination during skin epidermal stratification Nature Communications · 2021 · 51 citations
    12. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    13. Exploring Mechanical Niches Identified by Hair Follicle Compression and How These Transduce Proliferation and Differentiation Cues in Epidermally Derived cells. Durham e-Theses (Durham University) · 2019
    14. Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle Stem Cells · 2010 · 39 citations
    15. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis Development · 2007 · 28 citations
    16. Topically active vitamin D3 analogue, 1α,24-dihydroxy-cholecalciferol, has an anti-proliferative effect on the epidermis of guinea pig skin 1987 · 16 citations
    17. Type XVII collagen coordinates proliferation in the interfollicular epidermis eLife · 2017 · 124 citations
    18. ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes 2021 · 4 citations
    19. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    20. Epidermal cell proliferation and modulation of the protective potency of dexamethasone against phorbol ester-induced ornithine decarboxylase activity Carcinogenesis · 1989 · 1 citations
    21. An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal 1996
    22. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    23. N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release International Journal of Molecular Sciences · 2023
    24. RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling PLoS ONE · 2017 · 21 citations
    25. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    26. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016 · 43 citations
    27. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    28. EGF–FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs) Experimental Cell Research · 2014 · 29 citations
    29. Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis Development · 2003 · 421 citations
    30. Type XVII collagen suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis 2017