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    Alterations in Epidermal Stem Cells Within the Pilosebaceous Unit in Atrophic Acne Scars

    February 2024 in “ Australasian journal of dermatology ”
    Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Dae Hun Suh
    Studysummary This study found that in atrophic acne scars, inflammation infiltrates the pilosebaceous unit over time, affecting resident stem cells and hindering the normal regeneration of the epidermis and adnexal structures, leading to scarring.
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    Research cited in this study 8

    1. Development and Maintenance of Epidermal Stem Cells in Skin Appendages International journal of molecular sciences · 2020
    2. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020
    3. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    4. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    5. Strategic Targets in Acne: The Comedone Switch in Question Dermatology · 2015
    6. BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions Stem cell reports · 2014
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008