Alterations in Epidermal Stem Cells Within the Pilosebaceous Unit in Atrophic Acne Scars

February 2024 in “ Australasian journal of dermatology ”

Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Dae Hun Suh

TLDR Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.

The study investigates the role of epidermal stem cells in the development of atrophic acne scars. Researchers analyzed changes in collagen, elastic fibers, and HLA-DR expression in normal skin and inflammatory acne lesions over time. They found that inflammation progressively infiltrates the pilosebaceous units, leading to the destruction of their normal structure and a reduction in collagen and elastic fibers. Additionally, the expression of stem cell markers (CD34, p63, LGR6, and LGR5) and epidermal proliferation were significantly decreased in atrophic acne scar tissue compared to normal skin. These findings suggest that inflammation disrupts the normal regeneration of the interfollicular epidermis and adnexal structures, resulting in atrophic acne scars.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Development and Maintenance of Epidermal Stem Cells in Skin Appendages

15 citations, December 2020 in “International journal of molecular sciences”

Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.

research Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation

18 citations, November 2020 in “Frontiers in Cell and Developmental Biology”

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

research Wound Healing: A Cellular Perspective

1160 citations, November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations, August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Strategic Targets in Acne: The Comedone Switch in Question

47 citations, January 2015 in “Dermatology”

The best way to treat acne is to prevent healthy skin glands from turning into acne lesions by controlling the triggers early on.

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

research BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

50 citations, September 2014 in “Stem cell reports”

BLIMP1 is essential for skin maintenance but not for defining sebaceous gland progenitors.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Related Community Posts Join

6 / 55 results

community Clearing the air on how non-surgical treatments really work

18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A Scientific Perspective in Microneedling for Alopecia

in Microneedling 43 upvotes 5 years ago

The post and conversation are about microneedling as a treatment for alopecia. It provides a comprehensive review of scientific literature on the technique and its application.

Similar Research

5 / 1000+ results

research Cicatricial (Scarring) Alopecias: Comprehensive Review and Management

44 citations, April 2012 in “American Journal of Clinical Dermatology”

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

research Cicatricial Alopecias

May 2017 in “InTech eBooks”

Some hair loss disorders cause permanent loss due to scarring, and treatments like steroids don't always work well.

research What's New in Cicatricial Alopecia?

16 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.

research Platelet-Rich Plasma, a Powerful Tool in Dermatology

33 citations, February 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Platelet-Rich Plasma (PRP) shows promise for treating various skin conditions, but more research is needed to standardize its use.

research Histopathologic Evaluation of Alopecias

90 citations, June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.