Alterations in Epidermal Stem Cells Within the Pilosebaceous Unit in Atrophic Acne Scars

    February 2024 in “ Australasian journal of dermatology ”
    Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Dae Hun Suh
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    TLDR Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.
    The study investigates the role of epidermal stem cells in the development of atrophic acne scars. Researchers analyzed changes in collagen, elastic fibers, and HLA-DR expression in normal skin and inflammatory acne lesions over time. They found that inflammation progressively infiltrates the pilosebaceous units, leading to the destruction of their normal structure and a reduction in collagen and elastic fibers. Additionally, the expression of stem cell markers (CD34, p63, LGR6, and LGR5) and epidermal proliferation were significantly decreased in atrophic acne scar tissue compared to normal skin. These findings suggest that inflammation disrupts the normal regeneration of the interfollicular epidermis and adnexal structures, resulting in atrophic acne scars.
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