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Glossary Inflammatory Lesions

areas of tissue that are swollen, red, and painful

Inflammatory lesions are areas of tissue that have become swollen, red, and painful due to the body's immune response to injury, infection, or irritation. These lesions can occur in various parts of the body, including the skin, and are often characterized by the presence of immune cells and inflammatory mediators that aim to protect and heal the affected area.

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Research

5 / 1000+ results

research Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin

45 citations , September 2000 in “Archives of dermatology”

This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.

research Unraveling the Comedone Switch through Single-Cell Resolution of Human Acne Lesions

July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study used single-cell transcriptomic analysis to identify a specific cell population in acne patients' non-lesional skin, providing evidence for the comedone switch hypothesis by suggesting a shift towards infundibular differentiation at the expense of sebaceous gland maintenance.

Prevalence of Skin Lesions in Brazilian Patients With Inflammatory Bowel Disease

research Prevalence of skin lesions in a sample of Brazilian patients with inflammatory bowel disease

January 2023 in “Revista da Associação Médica Brasileira”

In this study, Brazilian patients with inflammatory bowel diseases had a higher prevalence of skin lesions, including alopecia, xerosis, striae, and acne, compared to healthy controls.

research Topical ALA-Photodynamic Therapy for Acne Can Induce Apoptosis of Sebocytes and Down-regulate Their TLR-2 and TLR-4 Expression

37 citations , January 2011 in “Annals of Dermatology”

In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.

research Oral Contraceptives as Anti-Androgenic Treatment of Acne

16 citations , July 2002 in “JOGC/Journal of obstetrics and gynaecology Canada”

This review discusses treatments for female acne, highlighting the effectiveness of low-dose oral contraceptives and noting their similar side effects to placebo; it reports no new clinical results.

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Community Join

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community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 3 years ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community [26M] Min 5 month progress, worse skin?

49 upvotes 2 years ago

A user experienced skin irritation and acne while using Minoxidil foam, but after stopping both the foam and a sea salt spray, their skin improved. They plan to try oral Minoxidil, suspecting the sea salt spray, not Minoxidil, was the main cause of their skin issues.

community Creatine made all my high DHT symptoms return

82 upvotes 1 year ago

Creatine may increase DHT levels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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Learn

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learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

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