The Relevance of Collagen XVII Expression in Epidermal Differentiation and Proliferation
September 2016
in “
Journal of dermatological science
”
Collagen XVII COL17 epidermal differentiation epidermal proliferation normal human epidermal keratinocytes NHEKs EGFR inhibitor AG1478 BMP2 BMP7 keratinocytes nail dystrophy Collagen 17 epidermal cells epidermal growth factor receptor inhibitor bone morphogenetic protein 2 bone morphogenetic protein 7 skin cells
TLDR Collagen XVII is crucial for skin cell growth and nail health.
The study investigated the role of Collagen XVII (COL17) in epidermal differentiation and proliferation. It was found that COL17 expression decreased when normal human epidermal keratinocytes (NHEKs) were induced to differentiate using the EGFR inhibitor AG1478 and BMP2/7. Knockdown of COL17 in NHEKs did not affect the expression of stemness or differentiation markers but did reduce cellular growth rates. Additionally, COL17-knockout mice exhibited nail dystrophy, suggesting that COL17 is crucial for maintaining the proliferative potential of keratinocytes. The findings highlighted COL17's significant role in regulating epidermal keratinocyte differentiation and proliferation.
