Cyclin D3 Deficiency Inhibits Skin Tumor Development But Does Not Affect Normal Keratinocyte Proliferation

    July 2017 in “ Oncology Letters ”
    Sung Hyun Lee, Xian Wang, Sun Hye Kim … Marcelo L. Rodriguez‐Puebla
    Studysummary This study found that ablating cyclin D3 in a Ras-dependent skin carcinogenesis model increased apoptosis in hair follicles, reducing papilloma development but potentially facilitating malignant progression when CDK6 is overexpressed.
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    Research cited in this study 1

    1. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005