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Glossary Cyclin D1

regulates cell cycle progression from G1 to S phase

Cyclin D1, also known as CCND1, is a protein that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where DNA replication occurs. It acts as a regulatory subunit for certain enzymes called cyclin-dependent kinases (CDKs), and its overexpression is often associated with various types of cancer, as it can lead to uncontrolled cell proliferation.

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research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

This study found that ablating cyclin D3 in a Ras-dependent skin carcinogenesis model increased apoptosis in hair follicles, reducing papilloma development but potentially facilitating malignant progression when CDK6 is overexpressed.

research Does D matter? The role of vitamin D in hair disorders and hair follicle cycling

98 citations , February 2010 in “Dermatology Online Journal”

This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.

research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

45 citations , September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.

research Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells

17 citations , April 2007 in “Kidney international”

This study found that 1,25 dihydroxyvitamin D3 significantly increased the expression and activity of vasculoprotective natriuretic peptide receptor-A in cultured inner medullary collecting duct cells, suggesting a potential mechanistic role in cardiovascular and renal benefits.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.

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community Seasonal Hairloss

5 upvotes 7 years ago

The user experiences increased hair loss in winter, possibly due to lack of sun and vitamin D, and is using finasteride and vitamin D3 supplements to address it. Suggestions include using a red light lamp and maintaining vitamin D intake.

community Thoughts on this hair product mix?

22 upvotes 2 months ago

The user is using a combination of 6% minoxidil, 0.3% finasteride spray in the morning, and 5% RU58841 in the evening for hair loss, considering it an aggressive approach. They are concerned about absorption issues and prefer topical treatments to avoid systemic side effects, especially while using anabolic steroids.

community My way to recovery and advice - Hope this helps (m20)

in Product 6 upvotes 1 year ago

A 20-year-old shared their experience of reversing hair loss without using minoxidil or finasteride, instead relying on supplements like biotin, collagen, fish oil, saw palmetto, and various vitamins. They emphasized the importance of a balanced supplement schedule and noted improvements in hair health without experiencing additional shedding.

community 2+ Years of Finasteride treatment - Stopped hair-loss, got regrowth, but

24 upvotes 1 year ago

The user experienced successful hair regrowth with Finasteride and Minoxidil but developed erectile dysfunction and abdominal pain, possibly due to medication or lifestyle changes. They plan to consult a urologist and consider adjusting medication or trying supplements like zinc, DIM, or boron.

community Finasteride is ****ing magical

in Update 314 upvotes 1 year ago

Finasteride has led to significant hair regrowth for some users, with noticeable improvements in two months, but side effects like erectile dysfunction have caused some to stop using it. Some users combine finasteride with minoxidil and other supplements, despite concerns about side effects.

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Genesis &D3 Organic Tresses LLCDanville, GA · US

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