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GlossaryEctodysplasin A

regulates development of skin, hair, teeth, and sweat glands

Ectodysplasin A (Eda) is a protein crucial for the development of ectodermal tissues, which include skin, hair, teeth, and sweat glands. Mutations in the EDA gene can lead to ectodermal dysplasias, a group of disorders characterized by abnormalities in these tissues, often resulting in sparse hair, missing teeth, and reduced ability to sweat.

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Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

4 citations, July 2020 in “Biochemical and Biophysical Research Communications”

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

Increased Expression of Ectodysplasin A2 Receptor EDA2R Is the Most Remarkable and Ubiquitous Aging-Related Transcriptional Hallmark

research Increased Expression of Ectodysplasin A2 Receptor EDA2R Is the Most Remarkable and Ubiquitous Aging-Related Transcriptional Hallmark

3 citations, August 2021 in “Research Square (Research Square)”

The most common sign of aging at the gene level is more Ectodysplasin A2 Receptor (EDA2R) being made.

research P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss

37 citations, April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

research Genetic and Molecular Aspects of Androgenetic Alopecia

24 citations, January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

Faculty Opinions Recommendation of Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

research Faculty Opinions Recommendation of Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

January 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The research found that certain genes are linked to male pattern baldness, but these same genes do not affect female pattern hair loss.

research Ectodysplasin Research: Where to Next?

30 citations, June 2014 in “Seminars in Immunology”

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

research Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

6 citations, August 2022 in “International Journal of Molecular Sciences”

EDA signaling is linked to skin disorders, various cancers, and liver disease.

A New Mutation Resulting in the Truncation of the TRAF6-Interacting Domain of XEDAR: A Possible Novel Cause of Hypohidrotic Ectodermal Dysplasia

research A New Mutation Resulting in the Truncation of the TRAF6-Interacting Domain of XEDAR: A Possible Novel Cause of Hypohidrotic Ectodermal Dysplasia

17 citations, August 2012 in “Journal of Medical Genetics”

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

research The Biology of Hair Diversity

47 citations, January 2013 in “International Journal of Cosmetic Science”

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

research XEDAR Activates the Non-Canonical NF-κB Pathway

18 citations, August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update

87 citations, March 2011 in “Australasian Journal of Dermatology”

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations, February 2012 in “British Journal of Dermatology”

AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.

research Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss

25 citations, July 2013 in “Journal of Dermatological Science”

Six new hair loss factors in men not linked to female hair loss.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations, July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Androgenetic Alopecia: A Review

153 citations, March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations, June 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

48 citations, May 2015 in “PLOS ONE”

DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.

research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

28 citations, April 2010 in “British Journal of Dermatology”

Genetic marker rs12558842 strongly linked to male hair loss.

research Towards a Consensus on How to Diagnose and Quantify Female Pattern Hair Loss – The Female Pattern Hair Loss Severity Index (FPHL-SI)

26 citations, December 2015 in “Journal of The European Academy of Dermatology and Venereology”

New method measures female hair loss: Female Pattern Hair Loss Severity Index (FPHL-SI).

research Female Pattern Hair Loss: Causes, Diagnosis, and Treatment Options

23 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

FPHL causes hair loss in women due to genetics and hormones; minoxidil and anti-androgens are treatments, and early intervention is advised.

research Androgenetic Alopecia: Drug Safety and Therapeutic Strategies

20 citations, January 2018 in “Expert Opinion on Drug Safety”

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations, February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Finasteride and Androgenic Alopecia: From Therapeutic Options to Medical Implications

13 citations, March 2019 in “Journal of Dermatological Treatment”

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

research Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population

9 citations, August 2013 in “PLOS ONE”

Genetic variants at 20p11 increase baldness risk in Chinese Han people.

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations, January 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research Alopecia and Techniques in Hair Restoration: An Overview for the Cosmetic Surgeon

5 citations, February 2019 in “Oral and Maxillofacial Surgery”

Hair loss can be reversed or even cured using advanced hair restoration techniques, with rare complications like swelling and bleeding.

research Cardiometabolic Risk Factors in Rosuvastatin-Treated Men with Mixed Dyslipidemia and Early-Onset Androgenic Alopecia

3 citations, May 2021 in “Molecules”

Rosuvastatin improves lipid levels, reduces inflammation, but worsens insulin sensitivity in men with early-onset hair loss.

research Genetic Variations Associated With Response to Dutasteride in the Treatment of Male Subjects With Androgenetic Alopecia

3 citations, September 2019 in “PLOS ONE”

Genetic variations affect dutasteride treatment response for male pattern hair loss.

research SNP Variation in Male Pattern Hair Loss in Russians with Different Dihydrotestosterone Levels

3 citations, December 2018 in “Meta Gene”

Certain gene variations increase male hair loss risk, influenced by hormone levels.