May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a low-viscosity triamcinolone acetonide serum, used with a derma stamp microneedling device, to improve targeted treatment of alopecia areata, reporting favorable drug solubility, spreadability, and permeation to hair follicles, while maintaining skin safety.
6 citations
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July 2024 in “Journal of Cosmetic Dermatology” In this study, researchers found that a composition containing mannose-6-phosphate significantly reduced the total skin pore area by 24% in women after 56 days and by 30.2% in men after 7 days, suggesting its effectiveness in improving pore appearance by targeting dermal and epidermal modifications.
July 2026 in “Current Medical Issues” In this study, using EMLA cream did not adequately control pain during and after scalp PRP injections for androgenetic alopecia, with anxiety and younger age linked to higher pain levels.
18 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.
19 citations
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March 2019 in “International Journal of Dermatology” In this study, researchers measured that the MMP drug delivery technique administered approximately 1,175 μg/cm² of medication into the dermis of human skin, but these findings are specific to the experimental protocol used.
November 2023 in “International Journal of Pharmaceutics” This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.
January 2008 in “Journal of Practical Medical Techniques” This study found that microencapsulated dermal papillae cells induced hair follicle regeneration in rat ears, differing from normal follicles in configuration, size, number, and differentiation degree.
June 2014 in “Biotechnology and Bioprocess Engineering” This study demonstrated that injecting reconstructed dermal papilla-like tissues in mice led to new hair growth, suggesting potential future applications in hair transplantation and baldness treatment.
January 2024 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study found that electronically-operated pneumatic injections for administering a peptide-hyaluronic acid combination were well tolerated and led to significant improvement in hair density and thickness for men with androgenic alopecia over six months, though the exact mechanism remains uncertain.
May 2026 in “Journal of the Egyptian Womenʼs Dermatologic Society” This review discusses microneedling radiofrequency in cosmetic dermatology, particularly for skin texture improvement and various conditions, and reports no new clinical results.
20 citations
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January 2013 in “Plastic & Reconstructive Surgery” In a swine model, this study found that a novel micro-coring needle device increased skin thickness and collagen content, suggesting potential as a safer, cost-effective alternative to laser resurfacing for skin rejuvenation.
September 2026 in “Surgical Neurology International” This case report describes a 28-year-old male who developed a subpericranial abscess, an unusual complication of subpericranial hematoma, potentially related to microneedling procedures, highlighting a risk of infection even without open wounds.
May 2014 in “Transfusion and Apheresis Science” PRP is a safe natural treatment that improves skin by reducing wrinkles and enhancing texture for up to 4 months.
21 citations
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June 2022 in “Pharmaceutics” This study found that bioactive extracts from goat placenta, particularly when delivered via dissolving microneedles, enhanced fibroblast proliferation and skin regeneration without being toxic to skin cells, suggesting a promising dermal application for improving skin health.
March 2016 in “Journal of aesthetic nursing” This article discusses the use of platelet-rich plasma (PRP) for skin rejuvenation and reports no new clinical results.
January 2026 in “Nanoscale Advances” This review provides an overview of microneedle-assisted photomedicine, detailing diagnostic and therapeutic strategies, design principles, and challenges for translating this approach to skin disease management.
November 2019 in “Quality in primary care” This paper describes Scalp Micropigmentation (SMP) as a cosmetic procedure that creates the appearance of hair through medical hairline tattoos, providing a non-surgical alternative to hair transplants with no downtime.
9 citations
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July 2017 in “Dermatologic Therapy” Two elderly men developed scalp inflammation after using a gel for skin lesions, which healed with treatment except for some permanent hair loss.
March 2024 in “Intisari Sains Medis” This narrative review reported that intradermal injection of autologous platelet-rich plasma showed objective improvement and increased patient satisfaction in treating periorbital wrinkles, though the authors noted the need for further rigorous studies to confirm these findings.
17 citations
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October 2011 in “International Journal of Immunopathology and Pharmacology” This study found that after 24 weeks of DPCP treatment for alopecia areata, there was a significant increase in new capillaries and hair regrowth detectable by videocapillaroscopy.
19 citations
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December 2015 in “Journal of Materials Chemistry B” This study found that using layer-by-layer encapsulation techniques on dermal papilla cells can support their function and may help treat hair loss when used in conjunction with freshly isolated epidermal cells.
March 2025 in “Archives of Plastic Surgery” This review suggests that combining platelet-rich plasma with microneedling may produce better hair restoration outcomes for androgenetic alopecia than using PRP injections alone, but calls for more standardized research.
3 citations
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December 2023 in “Biomedicines” This review discusses the mechanisms and potential benefits of platelet-rich plasma therapy for various skin conditions and reports no new clinical findings.
July 2026 in “Journal of the European Academy of Dermatology and Venereology” 1 citations
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January 2021 This review covers the use of platelet-rich plasma in dermatology for wound healing, hair restoration, skin rejuvenation, and dermal augmentation, and notes the need for standardized guidelines.
1 citations
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December 2014 in “Scanning” This study used multiphoton microscopy to successfully visualize rabbit skin microstructure, highlighting its noninvasive potential for future skin research related to diseases and wound healing.
19 citations
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July 2019 in “Biomedical Microdevices” This review discusses the safety and potential adverse events of microneedling as both a medical and consumer product, noting the need for further understanding; no new clinical results are presented.
11 citations
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March 2018 in “Journal of cosmetic and laser therapy” In this study, pneumatic injections of non-cross-linked hyaluronic acid were associated with improvements in skin texture, pores, wrinkles, and transepidermal water loss in healthy female volunteers.
March 2026 in “International Journal of Innovative Technologies in Social Science” This review summarizes current clinical evidence on platelet-rich plasma, highlighting its effectiveness in treating androgenetic alopecia and as an adjunctive therapy for acne scars, while noting challenges in standardizing preparation techniques.
February 2023 in “Journal of Advanced Research” This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.