Evaluation of Changes in Skin Biophysical Parameters and Appearance After Pneumatic Injections of Non-Cross-Linked Hyaluronic Acid in the Face

In a study conducted on 28 healthy female volunteers, pneumatic injections of non-cross-linked hyaluronic acid into the face over 5 consecutive weeks resulted in significant improvements in skin biophysical parameters and appearance. The study measured transepidermal water loss (TEWL), skin texture, pores, and wrinkles using the CK Multi-Probe Adapter and Visia system. Results showed a significant reduction in TEWL from 22.03 ± 7.15 g/h/m2 at baseline to 18.46 ± 4.70 g/h/m2 in week 4. Skin texture and pores also showed significant improvements at week 4, and skin wrinkles were improved at the 3-month follow-up. The study concluded that pneumatic injections of non-cross-linked hyaluronic acid are effective in enhancing skin parameters and reducing signs of aging.