February 2023 in “Journal of Advanced Research” This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.
January 2025 in “Journal of Aesthetic Nursing” This review discusses the expanding role of microneedling in dermatology, highlighting its enhanced effectiveness when combined with other treatments like minoxidil, platelet-rich plasma, and exosomes, but reports no clinical results.
January 2019 in “Clinical pediatric dermatology” This review discusses the use of follicular unit extraction and scalp micropigmentation in treating male pattern baldness, noting that scalp micropigmentation provides a non-surgical option to emulate natural hair appearance without downtime.
1 citations
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April 2023 in “The Egyptian Journal of Hospital Medicine” This review found that combining platelet-rich plasma with microneedling may enhance recovery and reduce toxicity in treating atrophic post-acne scars.
This study developed a personalized microneedle that delivers finasteride directly to the skin, facilitating a sustained release and potentially reducing side effects associated with oral administration.
January 2008 in “대한피부과학회지” This study found that micropigmentation effectively improved the cosmetic appearance of scalp and eyebrow scars in 94% of patients, with the pigments remaining safely in the superficial dermis after one year.
18 citations
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January 2021 in “Theranostics” This study found that actively targeted AN2728-loaded nanocarriers reduced inflammation and improved skin condition in a mouse model of psoriasiform inflammation compared to free drug and non-targeted nanoparticles.
August 2026 in “Journal of Cosmetic Dermatology” This study found that Plinest injections improved skin hydration and elasticity in the face, neck, and décolleté and were well-tolerated, with high patient satisfaction over a 4-month follow-up.
16 citations
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March 2009 in “Skin Pharmacology and Physiology” This study found that the penetration enhancer SEPA™ significantly increased both the speed and amount of hair growth from minoxidil in balding stumptail macaques compared to Rogaine®.
January 2014 in “Journal of Physiology & Pathology in Korean Medicine” Microneedle roller therapy can help hair grow.
2 citations
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January 2018 in “Biomolecules & therapeutics” This study found that polyamidoamine dendrimers can permeate skin's current conducting pores and alter the magnitude and direction of electroosmotic flow, affecting drug flux during iontophoresis.
21 citations
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December 2016 in “European journal of pharmaceutics and biopharmaceutics” This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.
61 citations
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January 2013 in “International Journal of Biological Macromolecules” This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.
April 2016 in “Journal of Investigative Dermatology” This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.
July 2003 in “Hair transplant forum international” PEMA handles on syringes improve comfort and efficiency in hair transplant procedures.
Microneedling improves the appearance and feel of post-burn scars.
13 citations
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February 2024 in “Clinical Cosmetic and Investigational Dermatology” This study demonstrated that intradermal treatment with a medical device using Polynucleotides High Purification Technology (PN HPT) significantly improved skin surface, firmness, pigmentation, and radiance in 30 Asian subjects, with benefits lasting up to six months and no adverse events reported.
In this 24-week study, oral supplementation with hydrolyzed low-molecular-weight porcine placental peptides significantly improved scalp elasticity, hair diameter, tensile strength, surface roughness, and luster compared to placebo, suggesting its potential as a nutritional intervention for age-related scalp and hair changes.
9 citations
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July 2019 in “Journal of cosmetic dermatology” This pilot study suggests that topical PRP may improve facial rejuvenation, with observed enhancements in collagen production and skin architecture over 8 weeks.
July 2025 in “Skin Appendage Disorders” In this study, researchers found that microinfusion of dutasteride using the MMP® technique did not show a statistical difference compared to placebo in clinical assessments for male androgenetic alopecia, though patients reported improvements in the vertex area.
1 citations
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July 2019 in “Hair transplant forum international” This article discusses the increasing global popularity of scalp micropigmentation for creating the illusion of hair density in hair restoration but does not present new research findings.
5 citations
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January 2020 in “International Journal of Trichology” This study found that both microneedling and microneedling with platelet-rich plasma improved hair thickness and density in male pattern alopecia, but no additional benefit was observed with the addition of platelet-rich plasma.
1 citations
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September 2019 in “Hair transplant forum international” This article introduces a needleless microjet injector using laser pulse energy for tattoo pigments in scalp micropigmentation, highlighting an almost painless procedure without anesthesia.
September 2022 in “Journal of The American Academy of Dermatology” In this study, the authors highlight the potential of intradermal microinjections of dutasteride as an adjunctive therapy for androgenetic alopecia, though they note that information on its effectiveness remains limited.
September 2025 in “Global Journal of Pharmacy & Pharmaceutical Sciences” This review analyzes PDRN's molecular mechanisms and therapeutic applications in anti-aging dermatology but reports no new clinical results, highlighting the need for more standardized protocols and long-term evaluations.
March 2026 in “Mendeley Data” This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.
This study describes a preliminary examination showing that an intraepidermal injection of autologous epidermal cell suspension contains a significant number of viable cells after 7 days of culture, suggesting potential use in treating skin disorders like alopecia and as an anti-aging therapy.
17 citations
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August 2021 in “Dermatologic surgery” This review found that microneedling is generally safe, with most adverse effects being minor and resolving quickly, though there is increased risk in patients with active infections, darker skin, or metal allergies.
January 2024 in “RSC pharmaceutics” This source discusses using stratum corneum ablation as a promising method to enhance transdermal drug delivery by temporarily removing the skin's outermost barrier to improve medication absorption.
August 2019 in “Journal of The American Academy of Dermatology” This article discusses the premade slit method in hair restoration surgery, emphasizing the importance of a tailored depth control instrument for optimal follicle implantation, but provides no new clinical results.