Improvements in Scalp Elasticity and Hair Properties Following Supplementation with Low-Molecular-Weight Porcine Placental Peptides (Placenderm®): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

February 2026

Yu-ri Gwon, A Reum Kim, Ji-Hae Lee, Ji Eun Lee, Hae Kwang Lee, Sun Young Choi, Ji Yeon Hong, Beom Joon Kim, Jinhak Kim, Miyoung Park

low-molecular-weight porcine placental peptides Placenderm scalp elasticity hair diameter tensile strength scanning electron microscopy cuticle damage hair luster

Studysummary In this 24-week study, oral supplementation with hydrolyzed low-molecular-weight porcine placental peptides significantly improved scalp elasticity, hair diameter, tensile strength, surface roughness, and luster compared to placebo, suggesting its potential as a nutritional intervention for age-related scalp and hair changes. Our plain-language summary of this paper — not a Tressless recommendation.

This study evaluated the effects of hydrolyzed low-molecular-weight porcine placental peptides (Placenderm®) on scalp and hair aging markers in a 24-week, randomized, double-blind, placebo-controlled trial with 100 adults. Participants receiving Placenderm® (500 mg/day) showed significant improvements in scalp elasticity, hair diameter, and tensile strength compared to the placebo group. Scanning electron microscopy revealed reduced hair surface roughness, indicating less cuticle damage. Additionally, hair luster and subjective satisfaction were higher in the intervention group, with no serious adverse events reported. The findings suggest that Placenderm® is a safe and effective nutritional intervention for improving age-related changes in scalp and hair.

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