In Vitro Biological Activity and In Vivo Human Study of Porcine Placenta Extract Loaded Nanovesicle Formulations for Skin and Hair Rejuvenation

The study explored the effects of porcine placenta extract (PPE) on skin and hair rejuvenation through in vitro and in vivo methods. In vitro, PPE enhanced cell viability, proliferation, and migration, and exhibited antioxidant and anti-inflammatory properties by reducing reactive oxygen species (ROS) and inhibiting lipoxygenase (LOX) and TNF-α production. In vivo, a human study with 12 participants showed that PPE-loaded serum significantly improved hair growth, skin hydration, and elasticity over a month. The findings suggested that PPE formulations could be effective for treating skin and hair aging. However, the study's strength was limited by the small number of participants.