January 2013 in “프로그램북(구 초록집)” This study found that sequential treatment with platelet-rich plasma injection followed by mesotherapy may promote hair growth in various alopecia cases, showing clinical improvement in hair count and thickness.
28 citations
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October 1992 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” In this study, Scalp Immersion Proxigraphy (SIP) was shown to produce more accurate measurements of linear hair growth rate than crude phototrichogram techniques, suggesting SIP's suitability for clinical trials monitoring hair growth.
March 2024 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān/Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān./Zahedan journal of researches in medical sciences” This case study describes the successful treatment of facial pigmentation using microneedling combined with platelet-rich plasma, suggesting high effectiveness with minimal side effects in this application.
January 2026 in “Journal of Cosmetic Dermatology” In this 10-patient exploratory study, the researchers found that topical application of 4-aminopyridine 5% combined with microneedling did not improve hair density or quality in men with androgenetic alopecia, suggesting limited efficacy in this context despite promising results in animal wound models.
February 2025 in “Brazilian Journal of Hair Health” This study found that multiparametric ultrasound effectively detects real-time scalp changes caused by vasoconstrictive cosmetic agents, demonstrating its potential as a non-invasive tool for evaluating trichological treatments.
April 2021 in “Journal of Investigative Dermatology” This study explored the use of an AI-driven device, HairMetrix, to quantitatively assess the effects of PRP treatments on scalp health in two Caucasian women with androgenetic alopecia, reporting increases in average hair width and follicle count after one treatment.
7 citations
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July 2022 in “Pharmaceutics” This study found that a dissolvable microneedle device delivering rapamycin and epigallocatechin gallate nanoparticles significantly enhanced hair regrowth in C57BL/6 mice within 7 days, demonstrating increased hair shaft growth and follicle density with minimal inflammation compared to untreated mice.
5 citations
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January 2014 in “Hospital pharmacy” This case report suggests that frequent application of diphenylcyclopropenone 2% solution to the scalp for alopecia areata may lead to scalp angioedema.
3 citations
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May 2025 in “Lasers in Surgery and Medicine” This study suggested that MRF may support skin regeneration and rejuvenation by promoting collagen synthesis and regulating factors involved in fibroblast activation and ECM remodeling, with preliminary findings indicating ADSCs might aid these processes.
December 2025 in “Aesthetic Cosmetology and Medicine” This study reported that platelet-rich fibrin (iPRF) therapy may improve scalp health and hair appearance in women, showing beneficial changes in scalp hydration, redness, oiliness, and hair density, thickness, and loss.
July 2018 in “Chinese Journal of Dermatology” The study found that a modified two-step enzyme digestion method was an efficient and rapid technique for isolating human axillary dermal papilla cells from a few specimens.
February 2017 in “Journal of Aesthetic Nursing” This systematic review explored the feasibility of adding skin needling to an aesthetic clinic's offerings, examining financial implications, time investment, and its integration with existing treatments. Various challenges and learning opportunities were noted, underscoring the complexity of introducing a new service.
October 2022 in “Skin appendage disorders” This study found that isolated scalp microneedling did not improve scalp coverage or hair density in male pattern hair loss patients, with no adverse events reported.
166 citations
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August 2011 in “Dermatologic Surgery” This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review explores the potential of microneedling as a drug delivery system for treating melasma, focusing on its mechanisms, safety, efficacy, and clinical advantages over conventional therapies like hydroquinone and lasers.
July 2026 in “Asian Journal of Pharmaceutical Sciences” The researchers designed a Janus microneedle system for treating vitiligo, which targets the skin’s layers to regulate the immune response, promote melanocyte regeneration, and enhance pigment transfer, offering a new precise treatment approach for this condition.
This review summarizes the diverse applications of platelet-rich plasma in dermatology, such as in hair loss, skin rejuvenation, scar repair, and wound healing, without presenting new clinical findings.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study used single-cell and spatial transcriptomic profiling to identify specific molecular markers in human follicular dermal papilla cells, enhancing understanding of their role in hair follicle development.
March 2019 in “Dermatologic Surgery” This journal overview describes the Dermatologic Surgery publication's focus on a wide range of skin surgery topics and reports no specific research findings.
8 citations
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March 2025 in “Journal of Drug Delivery Science and Technology” Dissolvable microneedles are a promising, painless method for effective skin treatments.
2 citations
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May 2024 in “PubMed” This study found that the current evidence is of low or very low certainty and thus does not clearly support using PRP in combination with microneedling or laser therapy for treating acne scars, indicating a need for further well-designed studies.
April 2025 in “Journal of Skin and Stem Cell” This review discusses the potential of polydeoxyribonucleotide (PDRN) for various dermatological treatments and highlights its significant effects on wound healing, anti-aging, acne scars, and hair loss, but emphasizes the need for further clinical studies.
April 2024 in “The Egyptian Journal of Hospital Medicine” This review highlights that microneedling is an effective and flexible technique for enhancing transdermal drug delivery, with numerous applications in both cosmetic and therapeutic dermatological treatments. The researchers note that further advancements are likely to increase its efficacy and safety.
March 2024 in “ACS Applied Materials & Interfaces” This study developed a delivery platform using hyaluronic acid-based dissolvable microneedles with nanoliposomes containing kopexil and kopyrrol, which showed improved hair regeneration for treating androgenetic alopecia in vivo at lower dosages compared to minoxidil.
This study reviewed the efficacy of hair intradermotherapy for treating androgenetic alopecia, finding that the technique, whether used alone or with other interventions, can increase hair density, reduce hair loss, and improve patient self-esteem, although professional supervision is recommended to minimize adverse effects.
January 2025 in “Annals of Dermatology” This study observed that although most patients recognize SMP as a medical procedure requiring physician oversight, many still receive treatment outside medical settings, underscoring the need for expanded access to physician-led services, enhanced public education, and strengthened regulatory enforcement for patient safety.
This study found that new methods for isolating human dermal papilla cells were more efficient than traditional methods, maintaining higher levels of specific markers and improving the cells' research potential.
September 1999 in “International Society of Hair Restoration Surgery” This abstract recounts the personal experience of the founder of DermMatch, Inc. with hair treatments and transplants but presents no new research findings.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a low-viscosity triamcinolone acetonide serum, used with a derma stamp microneedling device, to improve targeted treatment of alopecia areata, reporting favorable drug solubility, spreadability, and permeation to hair follicles, while maintaining skin safety.
6 citations
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July 2024 in “Journal of Cosmetic Dermatology” In this study, researchers found that a composition containing mannose-6-phosphate significantly reduced the total skin pore area by 24% in women after 56 days and by 30.2% in men after 7 days, suggesting its effectiveness in improving pore appearance by targeting dermal and epidermal modifications.