Dermatotoxicology of Microneedles in Humans

The document from July 4, 2019, discussed the use and potential side effects of microneedles (MNs) in collagen-induction therapy. Despite MNs being around for over four decades, they were not fully integrated into the medical system. Side effects such as infection, irritation, allergic reactions, hyperpigmentation, abnormal scarring, and granulomas were explored. Skin resealing times post MN therapy ranged from 15 minutes to 24 hours, indicating a potential for infection. Cases of irritant and allergic contact dermatitis were also reported. The document highlighted three cases of granulomatous reactions, irregular scarring in three patients, and post-inflammatory hyperpigmentation in 5 out of 36 patients following MN therapy. The authors recommended the use of test spots, post-procedural use of at least SPF 30 sunscreen, and avoidance of UV exposure to minimize post-therapy dyspigmentation.