16 citations
,
March 2021 in “EvoDevo” This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
11 citations
,
March 2020 in “Immunology” This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.
6 citations
,
January 2023 in “npj regenerative medicine” This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.
2 citations
,
November 2025 in “Cells” This review presents evidence supporting the potential of adipose-derived stem cell secretome as a promising cell-free therapy for skin repair, emphasizing its application in wound healing, alopecia, skin rejuvenation, and inflammatory skin diseases.
1 citations
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October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
November 2025 in “Frontiers in Immunology” This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.
71 citations
,
March 1995 in “Journal of The American Academy of Dermatology” This study concluded that combining vertical and transverse sections of scalp biopsy specimens improves diagnostic yield for certain hair disorders without increasing costs.
82 citations
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May 2020 in “International Journal of Molecular Sciences” This narrative review discusses the role of injectable biomaterials in dental tissue regeneration, highlighting their suitability for treating small, hard-to-access oral defects compared to pre-formed scaffolds, and explores the potential use of nanofibers in dental applications.
In this book, the authors provide an accessible overview of platelet concentrates and their dental applications, highlighting their role in tissue healing and regeneration, and reviewing recent studies on their efficacy in periodontal therapy, implant dentistry, and oral surgery.
22 citations
,
March 2021 in “Materials Today Bio” This review discusses recent advances in developmental tissue engineering for regenerating ectodermal appendages like teeth and glands, emphasizing biomaterial selection and cell culture strategies, but reports no new experimental results.
6 citations
,
January 2015 in “Journal of regenerative medicine & tissue engineering” This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.
November 2022 in “Regenerative Therapy” This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.
248 citations
,
November 2011 in “The EMBO Journal” This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.
123 citations
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January 2020 in “International Journal of Molecular Sciences” This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.
113 citations
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June 2015 in “Stem Cell Research & Therapy” This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.
43 citations
,
April 2021 in “Angiogenesis” This review examines the evolving understanding of lymphatic vessel development, emphasizing new cellular mechanisms and lineage diversity, while discussing experimental methods and identifying key knowledge gaps.
In this study, researchers found that myeloid cells can convert into keratinocytes during wound healing and contribute to hair follicle regeneration in mice.
34 citations
,
July 2022 in “Gels” This review explores the potential of alginate as a promising alternative to donor tissue for corneal transplantation due to its adaptability, transparency, and low immunogenicity, and discusses how chemical modifications can enhance its properties for use in corneal tissue engineering.
12 citations
,
April 2023 in “Frontiers in Materials” This review discusses the biofunctionalization of hydrogel scaffolds for vascular tissue regeneration and reports promising results from in vivo studies, such as improved angiogenesis and healing in pressure ulcers when using specific peptides.
10 citations
,
March 2024 in “Frontiers in Bioengineering and Biotechnology” This review examined photothermal hydrogels, biomedically innovative materials responsive to near-infrared stimulation, which hold promise for enhancing infection control and tissue regeneration. The authors highlighted their unique properties, construction methods, and potential applications while also discussing existing challenges and future research directions.
January 2025 in “Biomaterials Research” This study developed a novel zinc-releasing hydrogel, Zn-Gel, which promoted wound healing by controlling zinc ion release and demonstrated excellent compatibility and efficacy in enhancing cell proliferation, blood vessel formation, and tissue regeneration in vitro and in vivo settings.
11 citations
,
July 2012 in “Experimental dermatology” This article discusses the expression and potential new roles of innate immunity genes in CD49f(+) /CD34(+) hair follicle stem cells, but reports no new experimental results.
1 citations
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April 2023 in “Scientific Reports” This study reported that newly developed RADA16-I peptide hybrids, with active motifs like GHK and KGHK, demonstrated improved wound healing in a mouse skin injury model without cytotoxicity, suggesting they might be effective scaffolds for tissue engineering and regeneration.
42 citations
,
July 2021 in “Frontiers in Cell and Developmental Biology” This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.
9 citations
,
November 2024 in “Journal of Wound Management Official journal of the European Wound Management Association” Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.
3 citations
,
April 2022 in “Bioengineering” This review discusses pre-clinical research on ultrasound-mediated sonoporation for tissue regeneration and reports no clinical results; the authors suggest the method is safe and highlight challenges to clinical translation.
2 citations
,
June 2023 in “Gels” This study highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research, emphasizing their roles in controlled drug delivery, tissue regeneration, and treatment of various conditions, such as cardiac issues, joint diseases, and bone regeneration.
1 citations
,
July 2025 in “The Open Dermatology Journal” This study explores the transformative role of tissue engineering in cosmetics, highlighting innovations like lab-grown skin and personalized grafts that enhance product efficacy, offer ethical alternatives to animal testing, and address aesthetic issues such as scarring and aging.
57 citations
,
April 2009 in “Differentiation” This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.
52 citations
,
February 2012 in “PloS one” This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.