37 citations
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May 2021 in “Frontiers in Cell and Developmental Biology” This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.
10 citations
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February 2016 in “Journal of Dermatological Science” This article discusses the roles of dermal papilla and sheath cells in hair follicle formation and regeneration but reports no new clinical findings, emphasizing the need for further research on these fibroblasts.
9 citations
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November 2024 in “Biotechnology for Sustainable Materials” This paper critically reviews recent advances in the use of keratin-based biomaterials, highlighting their potential applications in wound healing, drug delivery, and tissue regeneration due to their biocompatibility, biodegradability, and ability to support cell growth.
6 citations
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April 2024 in “Journal of Investigative Dermatology” This review highlights recent advances in CRISPR-based lineage tracing methods that can improve our understanding of skin stem cell behavior, regeneration, and disease, with potential applications in organoids and model organisms.
2 citations
,
November 2025 in “International Journal of Molecular Sciences” This review reports that chitosan, a versatile polysaccharide, shows potential for various therapeutic applications due to its chemical modifications, notably in treating non-communicable diseases and wound healing, though further clinical study is needed to confirm these benefits.
April 2024 in “Journal of composites science” This review details how hydrogel composites play crucial roles in regenerative medicine, tissue engineering, and drug delivery systems, highlighting innovations in these applications and addressing challenges like bioactivity, biomechanical compatibility, and controlled drug release.
November 2023 in “Periodontology 2000” This narrative review examines the technological advancements and clinical applications of liquid injectable platelet-rich fibrin (i-PRF), discussing its use across regenerative periodontology, sports medicine, and more, as well as its potential as a drug delivery system.
1 citations
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February 2023 in “International Journal of Molecular Sciences” This review summarizes the research on bioactive materials that modulate the skin microenvironment to promote wound healing and highlights the essential role of the fascial layer, without presenting new experimental results.
1 citations
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May 2026 in “Nature Communications” This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.
118 citations
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December 2014 in “International Journal of Medical Sciences” This review discusses the potential of mesenchymal stem cells from the oral cavity for tissue regeneration in oral and maxillofacial surgery but reports no new clinical results.
425 citations
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January 2021 in “SN Applied Sciences” This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
10 citations
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May 2020 in “Clinical and Experimental Health Sciences” This study found that Tideglusib at 50nM stimulated Type-I collagen production in human gingival fibroblasts and osteoblasts, suggesting potential benefits for bone regeneration.
46 citations
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January 2020 in “Theranostics” This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.
October 2025 in “The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy” This study reviews modern techniques for bone tissue regeneration, addressing challenges like inadequate bone volume for dental implants, and highlights emerging methods such as guided bone regeneration, distraction osteogenesis, and stem cell therapy; it emphasizes the importance of personalized strategies tailored to individual patient needs.
9 citations
,
July 2022 in “Journal of Biological Chemistry” This study in mice found that WWP2 facilitates odontoblast differentiation and dentin formation by targeting PTEN for degradation, thereby enhancing KLF5 activity, which may suggest its crucial role in dental development.
41 citations
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September 2021 in “Materials” This review discusses the role of biomaterials and colloidal drug delivery systems in promoting tissue regeneration within regenerative medicine, but it reports no new clinical results.
11 citations
,
July 2024 in “Biomimetics” This manuscript explores the development and future potential of injectable biomimetic gels in biomedical applications, highlighting their promise in wound healing and tissue regeneration, while also acknowledging challenges like mechanical durability and scalable production still persist.
87 citations
,
March 2020 in “Australian Dental Journal” This review discusses different preparation and application methods of platelet-rich plasma in dental regenerative medicine and reports no new results, highlighting its potential and associated controversies.
5 citations
,
November 2024 in “Biomedicine & Pharmacotherapy” This study developed a carbohydrate chitosan-based biomaterial combined with a novel peptide to promote the chondrogenic differentiation of human adipose-derived stem cells, suggesting potential clinical applications for cartilage regeneration.
4 citations
,
February 2024 in “Scientific Reports” This study found that Platelet Rich Plasma is effective as a direct pulp capping agent, comparable to Mineral Trioxide Aggregate, but with potentially better cellular dentinogenic responses and homogenous tissue formation in dogs.
116 citations
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September 2020 in “Nature Communications” This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.
94 citations
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December 2018 in “Dentistry Journal” This review article explores the potential of various mesenchymal stem cell populations derived from oral tissues, such as DPSCs and hPCy-MSCs, in bone tissue engineering and regeneration, detailing their high plasticity and clinical applications in dental procedures.
19 citations
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November 2012 in “Cell Communication and Signaling” This study found that Fibroblast growth factor-9 (FGF-9) accelerates epithelial invagination in engineered ectodermal organs and suggests its potential role in organogenesis and regeneration research.
5 citations
,
November 2024 in “Advanced Science” This study reported the establishment of a chemically defined culture system that supports tooth reconstitution and detailed how co-stimulation of specific signaling pathways can sustain tooth development stages and initiate enamel formation, providing insights into tooth regeneration mechanisms.
January 2023 in “Wiadomości Lekarskie” In this study, the researchers shared their experiences with using local intracanal antibiotic therapy for treating endodontic bacterial infections, noting that current disinfectants, though effective, are highly toxic to human cells.
February 2015 in “Journal of Biomedical Materials Research Part B: Applied Biomaterials” This study suggests that 4-META resin may be more effective than cyanoacrylate for promoting wound healing in rats, as the wounds were covered by epithelial tissue faster with 4-META resin.
13 citations
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February 2020 in “Cold Spring Harbor Perspectives in Biology” This review discusses the evolution of lineage-tracing strategies over the past century, emphasizing their role in identifying progenitor cells and resolving debates about cellular origins, with no new results reported.
119 citations
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March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.
28 citations
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October 2013 in “Cornea” This review discusses the strategies and progress in developing bioengineered organ replacement therapies but reports no new clinical results, highlighting the potential for future regenerative solutions.
14 citations
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February 2014 in “Experimental Cell Research” This review examines the role of stem cells and their niches in continuously growing ectodermal organs like teeth, hair, and claws, providing insights from mouse models without presenting new research findings.