An Animal Study on the Effectiveness of Platelet-Rich Plasma as a Direct Pulp Capping Agent

February 2024 in “ Scientific Reports ”

Dina M. Elkady, Yara Rabia Helaly, Hala W. El Fayoumy, Huda O. AbuBakr, Aya M. Yassin, Naglaa A. AbdElKader, Dina B. E. Farag, Possy Moustafa Abd El Aziz, Antônio Scarano, Ahmad G. A. Khater

platelet-rich plasma mineral trioxide aggregate dentinogenic markers DSPP MEPE NES mRNA PRP MTA

TLDR Platelet-rich plasma is as effective as mineral trioxide aggregate for pulp capping and may offer better cellular responses.

This study evaluated the effectiveness of Platelet Rich Plasma (PRP) compared to Mineral Trioxide Aggregate (MTA) as direct pulp capping agents in 42 teeth from three mongrel dogs. After three months, both PRP and MTA showed similar hard tissue formation and dentin bridge thickness, with no significant differences. However, PRP resulted in homogenous mineralized tissues without cellular inclusions, unlike the osteodentin type seen with MTA. Additionally, PRP demonstrated significantly higher expression of dentinogenic markers DSPP, MEPE, and NES mRNA. The findings suggest that PRP is as effective as MTA in promoting mineralized tissue formation and may offer better cellular responses and dentin architecture, making it a promising alternative for direct pulp capping.

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An Animal Study on the Effectiveness of Platelet-Rich Plasma as a Direct Pulp Capping Agent

Research cited in this study

research Platelet-Rich Plasma and Regenerative Dentistry

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