The Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Innovations in the Clinical Application of Mesenchymal Stem Cells

    December 2014 in “ International Journal of Medical Sciences ”
    Marco Tatullo, Massimo Marrelli, Francesco Paduano
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    Studysummary This review discusses the potential of mesenchymal stem cells from the oral cavity for tissue regeneration in oral and maxillofacial surgery but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
    Regenerative medicine in oral and maxillofacial surgery focused on using mesenchymal stem cells (MSCs) to regenerate, repair, or replace tissues. Since 1990, advancements included growth factors, platelet concentrates, biomaterials, scaffolds, and autologous tissues. MSCs, derived from adult patients, overcame ethical issues and were seen as the future of regenerative medicine due to their potential and accessibility, particularly from the oral cavity. The goal was to regenerate whole organs or biological systems using stem cells, innovative scaffolds, and nano-engineering.
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