Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

The study evaluated the effects of Tideglusib on human periodontal cell lines, focusing on cytotoxicity and collagen expression. It found that Tideglusib at 200nM was cytotoxic to human gingival fibroblasts (hGF) and osteoblasts (hOB), but not to periodontal ligament fibroblasts (hPDLF). At 50nM, Tideglusib increased Type-I collagen expression in hGF and hOB, suggesting a potential positive effect on bone regeneration, while no significant effect was observed in hPDLF. Type-III collagen expression remained unchanged across all cell lines. The study concluded that Tideglusib was not cytotoxic at lower concentrations and may benefit bone regeneration more than periodontal regeneration.