Discovering New Progenitor Cell Populations Through Lineage Tracing and In Vivo Imaging
February 2020
in “
Cold Spring Harbor Perspectives in Biology
”
TLDR New methods have helped find cells that create other cells in the body.
The review discussed the evolution of lineage-tracing strategies over the past century and their role in identifying progenitor cells responsible for generating differentiated cell types during development, regeneration, and disease. It highlighted how technological advancements have enhanced lineage-tracing analyses, leading to the discovery of progenitor cells in various differentiation contexts. The review also provided examples where lineage-tracing experiments resolved debates and uncovered unexpected cellular origins, underscoring the ongoing nature of this research and the potential for new discoveries with emerging methodologies.
