Tooth, Hair, and Claw: Comparing Epithelial Stem Cell Niches of Ectodermal Appendages

The document is a review that compares the stem cell niches of ectodermal appendages, specifically teeth, hair, and claws, with a focus on their similarities and differences. It emphasizes the role of epithelial stem cells in the continuous growth and regeneration of these organs, and the importance of signaling pathways like Wnt and Hedgehog in regulating stem cell activity. The review also discusses the potential of Gli1 as a marker for stem cells across these different organs and the need for further research to confirm its role, particularly in the nail system. The significance of understanding these stem cell niches is underscored by their relevance to conditions like ectodermal dysplasias. The document does not include specific study participant numbers as it summarizes findings from multiple studies.