Tooth, Hair, and Claw: Comparing Epithelial Stem Cell Niches of Ectodermal Appendages

February 2014 in “ Experimental Cell Research ”

Adrien Naveau, Kerstin Seidel, Ophir D. Klein

hair epithelial stem cells Wnt signaling pathway Hedgehog signaling pathway Gli1 ectodermal dysplasias

TLDR The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.

The document is a review that compares the stem cell niches of ectodermal appendages, specifically teeth, hair, and claws, with a focus on their similarities and differences. It emphasizes the role of epithelial stem cells in the continuous growth and regeneration of these organs, and the importance of signaling pathways like Wnt and Hedgehog in regulating stem cell activity. The review also discusses the potential of Gli1 as a marker for stem cells across these different organs and the need for further research to confirm its role, particularly in the nail system. The significance of understanding these stem cell niches is underscored by their relevance to conditions like ectodermal dysplasias. The document does not include specific study participant numbers as it summarizes findings from multiple studies.

View this study on escholarship.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Nerve Dependence in Tissue, Organ, and Appendage Regeneration

228 citations, September 2012 in “Trends in Neurosciences”

Nerves are crucial for the regeneration of various body parts in many animals.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations, January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations, May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Epidermal Stem Cell Diversity and Quiescence

168 citations, August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

194 citations, May 2000 in “Journal of Investigative Dermatology”

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Related Community Posts Join

6 / 1000+ results

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 9 months ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

Similar Research