Tooth, Hair, and Claw: Comparing Epithelial Stem Cell Niches of Ectodermal Appendages

February 2014 in “ Experimental Cell Research ”

Adrien Naveau, Kerstin Seidel, Ophir D. Klein

hair epithelial stem cells Wnt signaling pathway Hedgehog signaling pathway Gli1 ectodermal dysplasias

TLDR The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.

The document is a review that compares the stem cell niches of ectodermal appendages, specifically teeth, hair, and claws, with a focus on their similarities and differences. It emphasizes the role of epithelial stem cells in the continuous growth and regeneration of these organs, and the importance of signaling pathways like Wnt and Hedgehog in regulating stem cell activity. The review also discusses the potential of Gli1 as a marker for stem cells across these different organs and the need for further research to confirm its role, particularly in the nail system. The significance of understanding these stem cell niches is underscored by their relevance to conditions like ectodermal dysplasias. The document does not include specific study participant numbers as it summarizes findings from multiple studies.

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