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GlossaryEctodermal Dysplasia

genetic disorders affecting skin, hair, nails, teeth, and sweat glands

Ectodermal Dysplasia (ED) refers to a group of genetic disorders that affect the development of the ectodermal layer, which is responsible for forming the skin, hair, nails, teeth, and sweat glands. Individuals with ED often experience symptoms such as sparse hair, missing or malformed teeth, and an inability to sweat properly, which can lead to overheating.

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WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

197 citations , June 2009 in “American journal of human genetics”

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

research Salivary Gland Function in Persons with Ectodermal Dysplasias

32 citations , September 2003 in “European journal of oral sciences”

People with ectodermal dysplasias often have reduced saliva production and should get saliva tests.

research Identification of Genes Involved in Inherited Ectodermal Dysplasias

January 2008

Mutations in specific genes cause different types of ectodermal dysplasias.

research Genetic Mapping of Hereditary Ectodermal Dysplasias and Hair Loss Genes

January 2011

Genetic mutations linked to ectodermal dysplasias and hair loss were identified in Pakistani families.

research Trichothiodystrophy: Review of Sulfur-Deficient Brittle Hair Syndromes and Association with the Ectodermal Dysplasias

144 citations , May 1990 in “Journal of the American Academy of Dermatology”

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community Hair loss research is a money grab

in Chat 217 upvotes 2 weeks ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community OFFICIAL Multi-Center Verteporfin Trial Recruitment

in Research/Science 252 upvotes 5 months ago

Recruitment for a verteporfin trial and a separate hair cloning trial using verteporfin and other methods is underway, with locations in Jordan, NYC, Beverly Hills, and Memphis. Dr. Bloxham is conducting the hair cloning trial, and interested participants are encouraged to contact him directly.

community Verteporfin and Microneedling

in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.