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GlossaryEctodermal Dysplasia

genetic disorders affecting skin, hair, nails, teeth, and sweat glands

Ectodermal Dysplasia (ED) refers to a group of genetic disorders that affect the development of the ectodermal layer, which is responsible for forming the skin, hair, nails, teeth, and sweat glands. Individuals with ED often experience symptoms such as sparse hair, missing or malformed teeth, and an inability to sweat properly, which can lead to overheating.

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research Transcriptional Activation of a Subset of Hair Keratin Genes by the NF-κB Effector p65/RelA

7 citations , November 2007 in “Differentiation”

The NF-κB effector p65/RelA activates hair keratin genes, aiding hair formation.

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

197 citations , June 2009 in “American journal of human genetics”

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

research Salivary Gland Function in Persons with Ectodermal Dysplasias

32 citations , September 2003 in “European journal of oral sciences”

People with ectodermal dysplasias often have reduced saliva production and should get saliva tests.

Alopecia in Congenital Hidrotic Ectodermal Dysplasia Responding to Treatment with a Combination of Topical Minoxidil and Tretinoin

research Alopecia in Congenital Hidrotic Ectodermal Dysplasia Responding to Treatment with a Combination of Topical Minoxidil and Tretinoin

20 citations , January 2009 in “International Journal of Dermatology”

Hair loss in Clouston's syndrome improved with minoxidil and tretinoin treatment.

research Clouston’s Syndrome: A Rare Case Report

August 2020 in “International Journal of Research in Dermatology”

Clouston's syndrome is a rare disorder affecting nails, hair, teeth, and skin, caused by a gene mutation, and currently has no treatment, only supportive care.

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community Hair loss research is a money grab

in Chat 225 upvotes 4 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community OFFICIAL Multi-Center Verteporfin Trial Recruitment

in Research/Science 251 upvotes 9 months ago

Recruitment for a verteporfin trial and a separate hair cloning trial using verteporfin and other methods is underway, with locations in Jordan, NYC, Beverly Hills, and Memphis. Dr. Bloxham is conducting the hair cloning trial, and interested participants are encouraged to contact him directly.

community Verteporfin and Microneedling

nkrata in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.