Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin

    April 2024 in “ Journal of Investigative Dermatology ”
    Jenny F. Nathans, Jessica Ayers, Jay Shendure, Cory L. Simpson
    Studysummary This review highlights recent advances in CRISPR-based lineage tracing methods that can improve our understanding of skin stem cell behavior, regeneration, and disease, with potential applications in organoids and model organisms.
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    Research cited in this study 14

    1. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    2. Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2022
    3. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    4. Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts Experimental Dermatology · 2020
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    7. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    8. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    9. Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis Current Topics in Developmental Biology · 2016
    10. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    11. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    12. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    13. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    14. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012