Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice
February 2022
in “
The Journal of clinical investigation/The journal of clinical investigation
”
Merkel cell carcinoma MCC Merkel cell polyomavirus MCPyV viral transforming antigens TAgs ATOH1 p53 Trp53 gene hair follicles skin tumors tumorigenesis apoptosis transcriptome analysis Merkel cell cancer skin cancer polyomavirus tumor antigens transcription factor gene p53 hair roots tumor growth cell death gene expression analysis
Studysummary This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.
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