Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

    February 2022 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Monique Verhaegen, Paul W. Harms, Julia J Van Goor, Jacob R. Arche, Matthew T. Patrick, D. Wilbert, H. Zabawa, Marina Grachtchouk, Chia-Jen Liu, Kevin Hu, Michael C. Kelly, Ping Chen, Thomas L. Saunders, Stephan Weidinger, Li-Jyun Syu, John S. Runge, Jóhann E. Guðjónsson, Sunny Y. Wong, Isaac Brownell, Marcin Cieślik, Aaron M. Udager, Arul M. Chinnaiyan, L.C. Tsoi, Andrzej A. Dlugosz
    Studysummary This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.
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