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research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

2 citations, April 2020 in “International Journal of Dermatology and Venereology”

Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.

research The Paradox of p53: What, How, and Why?

64 citations, July 2016 in “Cold Spring Harbor Perspectives in Medicine”

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

research Detection of Circulating Prostate Cancer Cells by Means of an Antibody-Conjugated Nanoparticulate Biosensor

March 2011 in “European Urology Supplements”

The document concludes that a new biosensor can efficiently detect prostate cancer cells and that standardized referrals help find significant cancers effectively.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community SUBE3 for sale in the gray market?

in Chat 3 upvotes 1 month ago

SCUBE3 is available online but poses risks like tumor promotion and high costs. Users advise against using it due to health concerns and inefficacy as a standalone treatment.

community Pyrilutamide 5 months results (before, after pics)

in Progress Pictures 193 upvotes 1 year ago

Tae147 has shared results of using pyrilutamide, a 5% concentration topical solution applied twice daily, in combination with minoxidil, to reduce scalp itchiness and hair shedding. Other users have shared their experiences with the treatment, as well as questions about its availability on the market.

community What makes them say exercise doesn't increase hair loss?

in Research/Science 45 upvotes 3 days ago

Exercise has minimal impact on hair loss, with weight lifting slightly increasing DHT and cardio potentially decreasing it. Finasteride and dutasteride are effective treatments for managing hair loss, even for those who exercise regularly.

community Did anybody not care at all about their hair until they started losing it?

in Chat 134 upvotes 3 months ago

People regret neglecting their hair until it started thinning, and they are now using treatments like finasteride, minoxidil, and microneedling. Some are considering stronger options like dutasteride due to mixed results.

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