Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
May 2016
in “
Cell Host & Microbe
”
Merkel cell polyomavirus MCPyV Merkel cell carcinoma MCC human dermal fibroblasts EGF FGF GSK3 inhibitor CHIR99021 WNT/β-catenin signaling pathway MMP genes UV radiation trametinib MAP kinase pathway skin cancer epidermal growth factor fibroblast growth factor glycogen synthase kinase 3 inhibitor WNT signaling matrix metalloproteinase genes ultraviolet radiation Mekinist
Studysummary In this study, human dermal fibroblasts were identified as natural host cells that support productive Merkel cell polyomavirus infection, and the MEK antagonist trametinib was introduced as an effective inhibitor to control the virus.
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