Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

    May 2016 in “ Cell Host & Microbe ”
    Wei Liu, Ruifeng Yang, Aimee Payne … Jianxin You
    Studysummary In this study, human dermal fibroblasts were identified as natural host cells that support productive Merkel cell polyomavirus infection, and the MEK antagonist trametinib was introduced as an effective inhibitor to control the virus.
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    Research cited in this study 3

    1. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012
    2. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    3. Merkel Cell Carcinoma: More Deaths but Still No Pathway to Blame Journal of Investigative Dermatology · 2007