28 citations,
January 2011 in “Hearing Research” Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.
14 citations,
February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
A low dose of rapamycin increases inner ear hair cell creation by boosting SOX2+ cell numbers.
Activin A increases inner ear hair cell development, while follistatin decreases it.
Activin A promotes ear hair cell development, while follistatin delays it.