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Glossaryp53 (p53 gene)

regulates cell division and prevents tumor formation

p53, also known as TP53 or Tumor Protein p53, is a crucial gene that produces a protein responsible for regulating cell division and preventing tumor formation. Often referred to as the "guardian of the genome," p53 helps repair damaged DNA or triggers cell death if the damage is irreparable, thereby playing a vital role in cancer prevention.

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research Tissue Regenerative Delays and Synthetic Lethality in Adult Mice After Combined Deletion of ATR and TRP53

99 citations, August 2009 in “Nature Genetics”

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations, April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Removing All Obstacles: A Critical Role for p53 in Promoting Tissue Renewal

30 citations, April 2010 in “Cell Cycle”

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

research Genetically Modified Laboratory Mice with Sebaceous Glands Abnormalities

22 citations, July 2016 in “Cellular and Molecular Life Sciences”

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

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