Deciphering Gene Regulatory Programs in Mouse Embryonic Skin Through Single-Cell Multiomics Analysis

    July 2025 in “ Genome biology ”
    Qiuting Deng, Pengfei Cai, Yingjie Luo, Zhongjin Zhang, Wen Ma, Zijie Huang, Xiaoya Chen, Shijie Hao, Weiguang Ma, Jiangshan Xu, Chunqing Wang, Mengnan Cheng, Xiumei Lin, Ru Zhou, Shanshan Duan, Junjie Chen, Ronghai Li, Xuyang Shi, Chang Liu, Liang Wu, Peng Gao, Jianting Li, Xiao Yang, Xiangdong Wang, Jun Xie, Longqi Liu, Yue Yuan, Chuanyu Liu
    TLDR HT-scCAT-seq helps understand gene regulation in embryonic skin development.
    The study employs HT-scCAT-seq, a high-throughput single-cell multiomics technology, to explore gene regulatory mechanisms in mouse embryonic skin development. By analyzing 64,408 cells, researchers identified 15 major cell types and 19 distinct clusters, revealing dynamic features and heterogeneity. The study highlights the role of transcription factors like RUNX2 and ALX4 in fibroblast differentiation and hair follicle development. It identifies 15,016 peak-gene links, including 12,687 regulatory elements linked to 3,166 differentially expressed genes. The findings provide insights into the regulatory dynamics and lineage commitment during skin development, offering a framework for studying regulatory mechanisms in various biological systems and diseases.
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