TLDR Different species use the same genes for tooth regeneration.
The study "Distinct tooth regeneration systems deploy a conserved battery of genes" investigated the genetic mechanisms of tooth regeneration in zebrafish and threespine sticklebacks, revealing that despite their evolutionary divergence and differences in dental morphology, both species utilized a conserved set of nine genes (bmpr1aa, bmp6, cd34, gli1, igfbp5a, lgr4, lgr6, nfatc1, and pitx2). This suggested a common epithelial progenitor cell type, termed "successional dental epithelium" (SDE), underlies tooth regeneration. The study also found that these genes are similarly expressed in mouse hair follicle epithelial stem cells, indicating a potential common genetic module across different vertebrate epithelial appendages. The findings highlighted the evolutionary conservation of regenerative mechanisms and suggested potential applications in regenerative therapies for humans.
Cited in this study
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35 citations
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February 2019 in “Cell Communication and Signaling” BMP6 and Wnt10b control whether hair follicles are resting or growing.
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
96 citations
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June 2017 in “Nature Communications” A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.
14 citations
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July 2014 in “Experimental Cell Research” The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.
60 citations
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April 2012 in “Physiology” The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
396 citations
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
51 citations
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April 2009 in “Journal of dermatological science” Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.
111 citations
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April 2007 in “Seminars in cell & developmental biology” Hair, teeth, and mammary glands develop similarly at first but use different genes later.
