Zinc Peroxide-Mediated In Situ Forming Hydrogels for Endogenous Tissue Regeneration

    January 2025 in “ Biomaterials Research ”
    Yeonjeong Kim, Kyung‐Min Park
    TLDR The new zinc peroxide hydrogel speeds up wound healing and tissue regeneration effectively.
    The study introduces a novel zinc peroxide-mediated hydrogel (Zn-Gel) designed to enhance wound healing and tissue regeneration. This bioactive hydrogel addresses challenges faced by previous zinc ion-releasing biomaterials, such as complex fabrication and rapid ion release, by offering controllable zinc ion release kinetics for up to 14 days. Zn-Gel, created by combining thiolated gelatin with zinc peroxide solutions, demonstrated excellent cytocompatibility and tissue compatibility in both in vitro and in vivo studies. It effectively accelerated wound healing by promoting cell proliferation, angiogenesis, hair follicle formation, and collagen deposition, highlighting its potential as an advanced material for endogenous tissue regeneration.
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