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This study found that fractional infrared technology may improve skin laxity and thickness in the cervical area without side effects in a small group of patients.

Transethosomes improve drug delivery through the skin and show promise for treating various conditions.

This study found that using elastic nano-liposomes to deliver palmitoylethanolamide improved its transdermal delivery and enhanced its skincare effects, with minimal cytotoxicity and no allergic reactions observed.

This study found that a nanotransferosome formulation of finasteride (FI-GO-NTF) in an Aloe vera gel significantly improved scalp permeation and antibacterial activity compared to standard formulations, suggesting safe and effective potential for alopecia areata treatment.

This review highlighted recent advances in nanocarrier-based topical delivery systems for skincare, emphasizing their potential to enhance ingredient stability, penetration, and targeted release while addressing specific pathophysiological skin concerns.

This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.

In this study, synthesized composite nanocarriers containing ribose and peptides demonstrated enhanced transdermal delivery, improved uptake by skin cells, promoted cell proliferation, enhanced antioxidant enzyme activities, and increased autophagy, suggesting a potential for more effective skin anti-aging treatments.

In this study, ketoconazole-loaded transferosomes were developed and demonstrated improved hair growth compared to a commercially available ketoconazole product, with the formulation showing enhanced drug penetration and minimal skin irritation in vivo.

In this study, the researchers reported that minoxidil-loaded transfersomes using a cyclodextrin strategy significantly increased drug stability, skin permeation, and hair regrowth in a mouse model of androgenetic alopecia compared to traditional formulations and commercial tinctures.

In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.

In this study, researchers developed de novo designed hetero-bifunctional proteins as an alternative approach for targeted protein degradation, successfully targeting BCL-xL for degradation in cells and inducing apoptosis, which may expand the range of addressable E3 ligases and disease targets.

This study analyzed the swelling behavior of human hair during permanent waving treatment, finding that both the microstructure and macrostructure of intermediate filaments swell simultaneously at the initial stage, and while partially destructed by reduction, they are considerably restored through oxidation.

In this study, collagen scaffolds functionalized with heparin and growth factors significantly enhanced long-term skin regeneration and growth in a sheep model of fetal skin defect, suggesting potential for prenatal spina bifida treatment.

Hair malformations may occur due to timing issues in hair development.

This review discusses the concept of epithelial-mesenchymal plasticity in wound healing and highlights restricting EMT for effective reepithelialization, but reports no new clinical results.

In this retrospective analysis, researchers evaluated 54 patients undergoing soft tissue reconstruction for scalp and forehead defects and reported excellent aesthetic outcomes with local flaps for defects up to 50 cm², while larger defects typically required additional skin grafting.

This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.

This study found that exposure to chlorine significantly reduced tensile properties in human hair compared to normal, while dyeing only affected some properties but not all.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.

This study examined the subcutaneous structures in forehead creases using cadavers and observed that dense fibrous structures connecting the dermis to the frontalis muscle, as well as specific epidermal and dermal characteristics, may contribute to the formation of these creases.

Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.

This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.

This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.

In this study, tubular 3D bioprinted structures made from sodium alginate and gelatin, containing NIH/3T3 fibroblast cells, demonstrated the ability for cell growth and network formation over 6 weeks, although structural tensile strength decreased with cell growth and polymer degradation.

In this study, researchers developed injectable micropore-forming hydrogels that enhance tissue adhesion strength and promote wound healing by allowing better cell infiltration and inducing hair follicle regeneration in skin incision wound models.

This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

In this study, formaldehyde hair straighteners significantly damaged curly hair by reducing break stress and break extension, while glyoxylic acid had a milder effect; both treatments increased shear modulus and decreased water sorption.

This review explores how epithelial cells from various niches in the skin respond and adapt during acute wound repair, highlighting the role of cellular plasticity in reepithelialization and restoring the skin's barrier function.