Investigation of the Anti-Aging Effects of Composite Nanocarriers Based on Autophagy Regulation and Oxidative Stress Inhibition

April 2025 in “ Cosmetics ”

Min Liu, Lei Ye, Lingling Jiang, Xi Wang, Cui Sun, Jiani Zheng, Wei Liu

composite nanocarriers RCDP NCs ribose collagen decarboxy carnosine HCL palmitoyl tripeptide-1 autophagy regulation oxidative stress inhibition HaCaT cells HSF cells antioxidant properties CAT SOD GSH-Px MDA nanocarriers antioxidants skin cells anti-aging

TLDR RCDP NCs are promising anti-aging cosmetic ingredients that improve skin health by reducing oxidative stress and enhancing cell function.

The study explores the anti-aging effects of composite nanocarriers (RCDP NCs) that include ribose, collagen, decarboxy carnosine HCL, and palmitoyl tripeptide-1. These nanocarriers enhance skin penetration, cellular uptake, and anti-aging efficacy by regulating autophagy and inhibiting oxidative stress. RCDP NCs showed improved cellular uptake and proliferation, reduced oxidative stress, and enhanced anti-aging effects compared to free RCDP. They demonstrated superior skin penetration, increased proliferation of HaCaT and HSF cells, and strong antioxidant properties by improving CAT, SOD, and GSH-Px activities while reducing MDA content. The study concludes that RCDP NCs have potential as effective anti-aging cosmetic ingredients, highlighting their ability to deliver bioactive substances and promote anti-aging effects in skin cells.

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