In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes

September 2023 in “ Molecules ”

Nisakorn Saewan, Ampa Jimtaisong, Nattakan Panyachariwat, Phanuphong Chaiwut

coffee berry extract nanoliposomes liposomal CBE phenolics human dermal fibroblasts nitric oxide inhibition superoxide dismutase activity anti-collagenase activities skin elasticity melanin levels CBE L-CBE

TLDR Liposomal coffee berry extract improves skin elasticity and reduces melanin better than regular extract.

This study investigated the encapsulation of coffee berry extract (CBE) in nanoliposomes to enhance its stability and anti-aging effects. The liposomal CBE (L-CBE) showed improved stability and a more consistent release of phenolics compared to free CBE. In vitro tests on human dermal fibroblasts indicated that L-CBE had lower toxicity and slightly higher anti-aging effects, including nitric oxide inhibition, enhanced superoxide dismutase activity, and anti-collagenase activities. In a clinical trial with 30 volunteers, L-CBE cream improved skin elasticity and reduced melanin levels more effectively than CBE cream after 4 weeks. The findings suggest that liposomal encapsulation of CBE enhances its potential as an anti-aging and whitening agent for cosmetic applications.

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In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes

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