In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes

This study explored the anti-aging effects of coffee berry extract (CBE) encapsulated in nanoliposomes (L-CBE) both in vitro and in vivo. The encapsulation improved the stability, skin penetration, and reduced toxicity of CBE. In vitro tests on human dermal fibroblasts showed that L-CBE had superior anti-aging effects, including enhanced superoxide dismutase activity and anti-collagenase activities. A clinical trial with 30 volunteers demonstrated that L-CBE cream improved skin elasticity and reduced melanin levels more effectively than free CBE after 4 weeks. The study concluded that L-CBE could be a potent anti-aging and whitening agent for cosmetic applications due to its improved stability and efficacy.