Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation

June 2024 in “ Pharmaceutics ”

Chuanpeng Ren, Yanyun Ma, Yizhen Wang, Dan Luo, Yanhan Hong, Xinyuan Zhang, Hexiang Mei, Wei Liu

Palmitoylethanolamide elastic nano-liposomes transdermal delivery stratum corneum anti-inflammatory skin barrier repair molecular docking PEA ENLs skin application topical skincare

TLDR PEA-ENL improves skin delivery and reduces inflammation without side effects.

The study explores the use of palmitoylethanolamide-incorporated elastic nano-liposomes (PEA-ENL) for enhanced transdermal delivery and anti-inflammatory effects. PEA-ENL demonstrated improved skin retention and transdermal delivery compared to free PEA, with significant anti-nociceptive and anti-inflammatory effects observed in HaCaT cells. These effects were mediated through the regulation of CB1 and TRPV1 receptors. The PEA-ENL also promoted cell migration and regulated genes related to anti-inflammatory and skin barrier repair functions. Human skin patch tests with 32 participants showed no allergic reactions, indicating safety. Despite its high cost, this ENL-based technology shows promise for precision skincare applications, targeting specific pharmacological pathways to treat skin sensitivity and aging.

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