Mechanistic Insights of Desmopressin Loaded Elastic Liposomes for Transdermal Delivery: HSPiP Predictive Parameters and Instrumental Based Evidences

November 2024 in “ International Journal of Pharmaceutics X ”

Afzal Hussain, Mohammad A. Altamimi, Musaad A. Alshammari

desmopressin acetate elastic liposomes transdermal delivery bioavailability stratum corneum ethanol surfactant FTIR DSC fluorescence microscopy SEM ODEL1 cohesive energies electrostatic energy hydrogen bonding

Studysummary In this study, desmopressin-loaded elastic liposomes (ODEL1) showed improved permeation and drug deposition across rat skin by altering the skin's cohesive energies and causing reversible changes on its surface.

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