Mechanistic Insights of Desmopressin Loaded Elastic Liposomes for Transdermal Delivery: HSPiP Predictive Parameters and Instrumental Based Evidences

The study examines the use of desmopressin acetate (DA) loaded elastic liposomes for transdermal delivery, aiming to enhance bioavailability and patient compliance compared to oral and nasal routes. Utilizing rat models, the research demonstrates that these cholesterol-free liposomes, characterized by their flexibility and deformability, can effectively penetrate the skin, facilitated by ethanol and surfactant components that induce reversible structural changes. Techniques such as FTIR, DSC, fluorescence microscopy, and SEM confirmed significant interactions with the skin's stratum corneum, enhancing drug permeation. The findings suggest that optimized liposomal formulations like ODEL1 could improve transdermal drug delivery by leveraging cohesive energies, electrostatic energy, and hydrogen bonding, offering a promising alternative to traditional delivery methods.