Sustained Postnatal Skin Regeneration Upon Prenatal Application of Functionalized Collagen Scaffolds

    November 2019 in “ Tissue Engineering Part A
    Corien Oostendorp, Paul J. Geutjes, Frank Smit … Toin H. Van Kuppevelt
    Studysummary In this study, collagen scaffolds functionalized with heparin and growth factors significantly enhanced long-term skin regeneration and growth in a sheep model of fetal skin defect, suggesting potential for prenatal spina bifida treatment.
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    Research cited in this study 10

    1. Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits Genes · 2017
    2. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    3. The Arrector Pili Muscle: The Bridge Between the Follicular Stem Cell Niche and the Interfollicular Epidermis Anatomical Science International · 2016
    4. Wool Keratin-Associated Protein Genes in Sheep: A Review Genes · 2016
    5. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    6. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    7. Characterization of the Human Hair Keratin-Associated Protein 2 (KRTAP2) Gene Family Journal of Investigative Dermatology · 2012
    8. Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression Experimental Dermatology · 2011
    9. Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles Differentiation · 2009
    10. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007

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    2. Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration PloS one · 2016
    3. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    4. The Influence of Flightless I: Regeneration Versus Wound Healing Journal of Investigative Dermatology · 2011