A Multiaxial Bioreactor Integrated With an Environmental Monitoring System for Tissue-Engineered Skin Grafts
January 2026
in “
Advanced Healthcare Materials
”
TLDR The new bioreactor improves skin grafts by evenly stretching cells and monitoring conditions for better growth.
The study introduces a novel multiaxial bioreactor system designed to enhance the maturation of tissue-engineered skin grafts. Unlike conventional bioreactors that offer limited directional stretching, this system employs a Hoberman ring design to provide uniform multiaxial stretching, ensuring even cellular distribution and orientation. The bioreactor integrates continuous environmental monitoring with sensors for pH, dissolved oxygen, glucose, lactate, and media level, facilitating optimal conditions for tissue growth. The cyclic multiaxial stretching significantly improved the proliferation of dermal fibroblasts and the integrity of epidermal keratinocytes, suggesting that this bioreactor offers a robust platform for advancing regenerative medicine applications. The authors report no conflicts of interest, and data supporting the study's findings are available upon request.
