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    Formulation and Evaluation of Repurposed Ketoconazole-Loaded Transferosomal Gel for Enhanced Trichogenic Effects

    April 2025 in “ Clinical and Translational Discovery ”
    Monu Mishra, Ganesh A. Thakur, Pallavi Bassi … Vetriselvan Subramaniyan
    Studysummary In this study, ketoconazole-loaded transferosomes were developed and demonstrated improved hair growth compared to a commercially available ketoconazole product, with the formulation showing enhanced drug penetration and minimal skin irritation in vivo.
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    Research cited in this study 9

    1. Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management Journal of Drug Delivery Science and Technology · 2023
    2. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    3. Androgens in Women: Role in Androgen-Mediated Cutaneous Disorders Journal of The American Academy of Dermatology · 2018
    4. Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review PubMed · 2016
    5. Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice Toxicological Research · 2016
    6. Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice ISRN Pharmacology (Print) · 2014
    7. Reversal of Androgenetic Alopecia by Topical Ketoconazole: Relevance of Anti-Androgenic Activity Journal of Dermatological Science · 2006
    8. Allergic Contact Dermatitis from Minoxidil Contact Dermatitis · 1995
    9. Quantitative Models for the Study of Hair Growth In Vivo Annals of the New York Academy of Sciences · 1991