Formulation and Evaluation of Repurposed Ketoconazole-Loaded Transferosomal Gel for Enhanced Trichogenic Effects

    April 2025 in “ Clinical and Translational Discovery ”
    Monu Mishra, Ganesh A. Thakur, Pallavi Bassi, Gurpreet Kaur, Thakur Gurjeet Singh, Narinderpal Kaur, Ling Shing Wong, Satyanarayana Reddy, Gowtham Kuppusamy, Vinoth Kumarasamy, Gaurav Gupta, Vetriselvan Subramaniyan
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    TLDR The ketoconazole gel improved hair growth and is a promising treatment for hair loss.
    The study developed a ketoconazole-loaded transferosomal gel to enhance hair growth and skin permeability for treating androgenic alopecia (AGA). Using a Quality by Design approach, the formulation was optimized for critical attributes like particle size and entrapment efficiency. In vivo studies on 12 male albino rats showed improved hair growth with the ketoconazole-loaded gel compared to control groups over 27 days, with no significant skin irritation. The gel demonstrated superior hair growth efficacy and sustained drug release compared to a marketed formulation, suggesting it as a promising alternative treatment for AGA.
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      in Ketoconazole 1 week ago
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      in Ketoconazole  3 upvotes 2 weeks ago
      Ketoconazole shampoo can be very drying, especially for curly hair, and may not be suitable for those who need to maintain moisture. Some users suggest using oils or masks to mitigate dryness, while others recommend avoiding it unless necessary for conditions like dandruff.

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