Micropore-Forming Photocurable Tissue Adhesive Promotes Cell Infiltration for Wound Healing
September 2025
in “
Acta Biomaterialia
”
Studysummary In this study, researchers developed injectable micropore-forming hydrogels that enhance tissue adhesion strength and promote wound healing by allowing better cell infiltration and inducing hair follicle regeneration in skin incision wound models. Our plain-language summary of this paper — not a Tressless recommendation.
The study introduces a micropore-forming photocurable tissue adhesive designed to enhance cell infiltration and promote wound healing. Utilizing liquid–liquid phase separation (LLPS) technology, the researchers developed two types of hydrogels, μCN and μFN, which are injectable and enzymatically degradable. These hydrogels demonstrated strong adhesive properties to various tissues, including the collagen membrane, heart, stomach, and large intestine, while their microporous structure facilitated fibroblast infiltration. This innovative tissue adhesive shows significant potential for improving wound healing and reducing postoperative complications by balancing tissue adhesion strength and degradation rate.
