Micropore-Forming Photocurable Tissue Adhesive Promotes Cell Infiltration for Wound Healing

The study introduces a micropore-forming photocurable tissue adhesive designed to enhance cell infiltration and promote wound healing. Utilizing liquid–liquid phase separation (LLPS) technology, the researchers developed two types of hydrogels, μCN and μFN, which are injectable and enzymatically degradable. These hydrogels demonstrated strong adhesive properties to various tissues, including the collagen membrane, heart, stomach, and large intestine, while their microporous structure facilitated fibroblast infiltration. This innovative tissue adhesive shows significant potential for improving wound healing and reducing postoperative complications by balancing tissue adhesion strength and degradation rate.