Minoxidil Cyclodextrin Complexes and Their Inclusion in Transfersomes for the Enhancement of Therapeutic Effect on Androgenic Alopecia

    August 2024 in “ Journal of Drug Delivery Science and Technology ”
    Xia Kong, Xiaoya Pang, Ruifen Wang, Qian Zhang, Xiangqi Kong, H. Li, Xiaxia Liu, Shaosan Kang, Hao Sui, Qingping Tian
    TLDR The new minoxidil formulation could better promote hair growth for treating androgenic alopecia.
    This study aimed to enhance the therapeutic effect of minoxidil (MXD) for treating androgenic alopecia (AGA) by developing a novel formulation using cyclodextrin (CD) inclusion complexes within transfersomes. The researchers used molecular docking to identify sulfobutylether-β-cyclodextrin (SBE-β-CD) as the most suitable CD for forming a stable inclusion complex with MXD. The optimized formulation, MXD/SCD@TFs, showed improved drug loading (DL) and encapsulation efficiency (EE) compared to traditional methods. The new formulation demonstrated significant potential in promoting hair growth in AGA model mice, suggesting it could be a better candidate for MXD treatment of AGA.
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