De Novo Designed Bifunctional Proteins for Targeted Protein Degradation

    December 2025
    B. Mylemans, Boguslawa Korona, Amanda Acevedo-Jake … Derek N. Woolfson
    Studysummary In this study, researchers developed de novo designed hetero-bifunctional proteins as an alternative approach for targeted protein degradation, successfully targeting BCL-xL for degradation in cells and inducing apoptosis, which may expand the range of addressable E3 ligases and disease targets.
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